Mast cells in rheumatoid arthritis

Nicola Maruotti, Enrico Crivellato, Francesco Paolo Cantatore, Angelo Vacca, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) is a chronic disease of joints that is characterized by inflammation, abnormal cellular and humoral immune responses, and synovial hyperplasia. Mast cells (MCs) are involved in several of these inflammatory and immune events. MC-derived mediators induce edema, destroy connective tissue, and are involved in lymphocyte chemotaxis and infiltration and in pathological fibrosis of RA joints. Moreover, MCs are involved in angiogenesis during RA, and their proteolytic activity results in cartilage destruction and bone remodeling. Lastly, MCs could be a target in the treatment of RA.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalClinical Rheumatology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2007

Fingerprint

Mast Cells
Rheumatoid Arthritis
Joints
Bone Remodeling
Chemotaxis
Humoral Immunity
Cellular Immunity
Connective Tissue
Cartilage
Hyperplasia
Edema
Fibrosis
Chronic Disease
Lymphocytes
Inflammation
Therapeutics

Keywords

  • Angiogenesis
  • Mast cells
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Maruotti, N., Crivellato, E., Cantatore, F. P., Vacca, A., & Ribatti, D. (2007). Mast cells in rheumatoid arthritis. Clinical Rheumatology, 26(1), 1-4. https://doi.org/10.1007/s10067-006-0305-3

Mast cells in rheumatoid arthritis. / Maruotti, Nicola; Crivellato, Enrico; Cantatore, Francesco Paolo; Vacca, Angelo; Ribatti, Domenico.

In: Clinical Rheumatology, Vol. 26, No. 1, 01.2007, p. 1-4.

Research output: Contribution to journalArticle

Maruotti, N, Crivellato, E, Cantatore, FP, Vacca, A & Ribatti, D 2007, 'Mast cells in rheumatoid arthritis', Clinical Rheumatology, vol. 26, no. 1, pp. 1-4. https://doi.org/10.1007/s10067-006-0305-3
Maruotti N, Crivellato E, Cantatore FP, Vacca A, Ribatti D. Mast cells in rheumatoid arthritis. Clinical Rheumatology. 2007 Jan;26(1):1-4. https://doi.org/10.1007/s10067-006-0305-3
Maruotti, Nicola ; Crivellato, Enrico ; Cantatore, Francesco Paolo ; Vacca, Angelo ; Ribatti, Domenico. / Mast cells in rheumatoid arthritis. In: Clinical Rheumatology. 2007 ; Vol. 26, No. 1. pp. 1-4.
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