Abstract
Rheumatoid arthritis (RA) is a chronic disease of joints that is characterized by inflammation, abnormal cellular and humoral immune responses, and synovial hyperplasia. Mast cells (MCs) are involved in several of these inflammatory and immune events. MC-derived mediators induce edema, destroy connective tissue, and are involved in lymphocyte chemotaxis and infiltration and in pathological fibrosis of RA joints. Moreover, MCs are involved in angiogenesis during RA, and their proteolytic activity results in cartilage destruction and bone remodeling. Lastly, MCs could be a target in the treatment of RA.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Clinical Rheumatology |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2007 |
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Keywords
- Angiogenesis
- Mast cells
- Rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Mast cells in rheumatoid arthritis. / Maruotti, Nicola; Crivellato, Enrico; Cantatore, Francesco Paolo; Vacca, Angelo; Ribatti, Domenico.
In: Clinical Rheumatology, Vol. 26, No. 1, 01.2007, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mast cells in rheumatoid arthritis
AU - Maruotti, Nicola
AU - Crivellato, Enrico
AU - Cantatore, Francesco Paolo
AU - Vacca, Angelo
AU - Ribatti, Domenico
PY - 2007/1
Y1 - 2007/1
N2 - Rheumatoid arthritis (RA) is a chronic disease of joints that is characterized by inflammation, abnormal cellular and humoral immune responses, and synovial hyperplasia. Mast cells (MCs) are involved in several of these inflammatory and immune events. MC-derived mediators induce edema, destroy connective tissue, and are involved in lymphocyte chemotaxis and infiltration and in pathological fibrosis of RA joints. Moreover, MCs are involved in angiogenesis during RA, and their proteolytic activity results in cartilage destruction and bone remodeling. Lastly, MCs could be a target in the treatment of RA.
AB - Rheumatoid arthritis (RA) is a chronic disease of joints that is characterized by inflammation, abnormal cellular and humoral immune responses, and synovial hyperplasia. Mast cells (MCs) are involved in several of these inflammatory and immune events. MC-derived mediators induce edema, destroy connective tissue, and are involved in lymphocyte chemotaxis and infiltration and in pathological fibrosis of RA joints. Moreover, MCs are involved in angiogenesis during RA, and their proteolytic activity results in cartilage destruction and bone remodeling. Lastly, MCs could be a target in the treatment of RA.
KW - Angiogenesis
KW - Mast cells
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=33845883541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845883541&partnerID=8YFLogxK
U2 - 10.1007/s10067-006-0305-3
DO - 10.1007/s10067-006-0305-3
M3 - Article
C2 - 16741781
AN - SCOPUS:33845883541
VL - 26
SP - 1
EP - 4
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 1
ER -