Mast cells in the islets of langerhans - A study of their behaviour in connection with diabetes and with insular amyloidosis

M. Mlac, M. Melato, G. Marin

Research output: Contribution to journalArticle

Abstract

The number of mast cells in the islets of Langerhans in 60 cases was determined in an autopsy study. The 60 patients were divided into 4 groups, distinguishing between those with diabetes, insular amyloidosis, those with both these pathological conditions and those with neither diabetes nor insular amyloidosis. As compared with the control group, it was discovered that there was a sharp increase in mast cells in the group with insular amyloidosis and in the group with diabetes; the number of mast cells tended to increase even more in the presence of both pathological conditions. With these data in hand, it is assumed that the increase in mast cells in the islets of Langerhans is not only due to the presence of amyloidosis, but that it is also brought about as a direct consequence of diabetes.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume365
Issue number3
DOIs
Publication statusPublished - Sep 1975

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Amyloidosis
Islets of Langerhans
Mast Cells
Autopsy
Hand
Control Groups

Keywords

  • Aging
  • Amyloidosis
  • Diabetes Mellitus
  • Islets of Langerhans
  • Mast Cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy
  • Medicine(all)

Cite this

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abstract = "The number of mast cells in the islets of Langerhans in 60 cases was determined in an autopsy study. The 60 patients were divided into 4 groups, distinguishing between those with diabetes, insular amyloidosis, those with both these pathological conditions and those with neither diabetes nor insular amyloidosis. As compared with the control group, it was discovered that there was a sharp increase in mast cells in the group with insular amyloidosis and in the group with diabetes; the number of mast cells tended to increase even more in the presence of both pathological conditions. With these data in hand, it is assumed that the increase in mast cells in the islets of Langerhans is not only due to the presence of amyloidosis, but that it is also brought about as a direct consequence of diabetes.",
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