Mast cells positive to tryptase and tumour-associated macrophages correlate with angiogenesis in locally advanced colorectal cancer patients undergone to surgery

Michele Ammendola, Rosa Patruno, Rosario Sacco, Ilaria Marech, Giuseppe Sammarco, Valeria Zuccalà, Maria Luposella, Nicola Zizzo, Claudia Gadaleta, Mariangela Porcelli, Cosmo Damiano Gadaleta, Domenico Ribatti, Girolamo Ranieri

Research output: Contribution to journalArticle

Abstract

Objective. The density of mast cells positive to tryptase (MCDPT) and tumor-associated macrophages (TAMs) were evaluated in a series of 87 patients with stage B and C colorectal cancer who had undergone radical surgery. Methods. MCDPT, TAMs, microvascular density (MVD), endothelial area (EA) and CD8+ tumor infiltrating lymphocytes (CD8+ TILs) were evaluated in tumor tissue samples by immunohistochemistry and image analysis. Each of the above parameters was correlated with the others and with the main clinico-pathological features. Results. A significant correlation between MCDPT, TAMs, MVD and EA was found by Pearson t-test analysis. With special references to the clinico-pathological features a minimal correlation using univariate analysis was found but it was not retained at multivariate analysis. Conclusions. Our data suggest that MCDPT and TAMs are linked in the tumor microenvironment and play a role in CRC angiogenesis in a synergistic manner. The assessment of the combination MCDPT and TAMs could be evaluated as a target of novel anti-angiogenic therapies in colorectal cancer patients.

Original languageEnglish
Pages (from-to)533-540
JournalExpert Opinion on Therapeutic Targets
Volume20
Issue number5
DOIs
Publication statusAccepted/In press - Mar 17 2016

Keywords

  • Angiogenesis
  • colorectal cancer
  • macrophages
  • mast cells
  • tryptase

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Fingerprint Dive into the research topics of 'Mast cells positive to tryptase and tumour-associated macrophages correlate with angiogenesis in locally advanced colorectal cancer patients undergone to surgery'. Together they form a unique fingerprint.

Cite this