Abstract
Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.
| Original language | English |
|---|---|
| Pages (from-to) | 1947-1956 |
| Number of pages | 10 |
| Journal | European Journal of Cancer |
| Volume | 13 |
| Issue number | 48 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Breast surgery
- Breast surgery in europe
- Mastectomies
- Mastectomy
- Mastectomy rates
- Mastectomy trends
- Rates in europe
- Surgery for breast cancer
- Surgery trends in europe
- Trends in europe
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Mastectomy trends for early-stage breast cancer : A report from the EUSOMA multi-institutional European database. / Garcia-Etienne, Carlos A.; Tomatis, Mariano; Heil, Joerg; Friedrichs, Kay; Kreienberg, Rolf; Denk, Andreas; Kiechle, Marion; Lorenz-Salehi, Fatemeh; Kimmig, Rainer; Emons, Günter; Danaei, Mahmoud; Heyl, Volker; Heindrichs, Uwe; Rageth, Christoph J.; Janni, Wolfgang; Marotti, Lorenza; Del Turco, Marco Rosselli; Ponti, Antonio; Cataliotti, Luigi; Cretella, Elisabetta; Van Dam, Peter; Emons, Adelgund; Gyr, Thomas; Hils, Rita; Kern, Peter; Koehler, Uwe; Kuemmel, Sherko; Liedtke, Doris; Luini, Alberto; Moebus, Volker; Neumann, Monika; Paepke, Stefan; Pagani, Olivia; Pavesi, Lorenzo; Sarlos, Dimitri; Schlotfeldt, Tim; Sohn, Cristof; Spelsberg, Angela; Staelens, Gracienne; Taffurelli, Mario; Tinterri, Corrado; Vergin, Iris B.; Zemmler, Thomas; Wagner, Dominik; eusomaDB Working Group.
In: European Journal of Cancer, Vol. 13, No. 48, 2012, p. 1947-1956.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mastectomy trends for early-stage breast cancer
T2 - A report from the EUSOMA multi-institutional European database
AU - Garcia-Etienne, Carlos A.
AU - Tomatis, Mariano
AU - Heil, Joerg
AU - Friedrichs, Kay
AU - Kreienberg, Rolf
AU - Denk, Andreas
AU - Kiechle, Marion
AU - Lorenz-Salehi, Fatemeh
AU - Kimmig, Rainer
AU - Emons, Günter
AU - Danaei, Mahmoud
AU - Heyl, Volker
AU - Heindrichs, Uwe
AU - Rageth, Christoph J.
AU - Janni, Wolfgang
AU - Marotti, Lorenza
AU - Del Turco, Marco Rosselli
AU - Ponti, Antonio
AU - Cataliotti, Luigi
AU - Cretella, Elisabetta
AU - Van Dam, Peter
AU - Emons, Adelgund
AU - Gyr, Thomas
AU - Hils, Rita
AU - Kern, Peter
AU - Koehler, Uwe
AU - Kuemmel, Sherko
AU - Liedtke, Doris
AU - Luini, Alberto
AU - Moebus, Volker
AU - Neumann, Monika
AU - Paepke, Stefan
AU - Pagani, Olivia
AU - Pavesi, Lorenzo
AU - Sarlos, Dimitri
AU - Schlotfeldt, Tim
AU - Sohn, Cristof
AU - Spelsberg, Angela
AU - Staelens, Gracienne
AU - Taffurelli, Mario
AU - Tinterri, Corrado
AU - Vergin, Iris B.
AU - Zemmler, Thomas
AU - Wagner, Dominik
AU - eusomaDB Working Group
PY - 2012
Y1 - 2012
N2 - Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.
AB - Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.
KW - Breast surgery
KW - Breast surgery in europe
KW - Mastectomies
KW - Mastectomy
KW - Mastectomy rates
KW - Mastectomy trends
KW - Rates in europe
KW - Surgery for breast cancer
KW - Surgery trends in europe
KW - Trends in europe
UR - http://www.scopus.com/inward/record.url?scp=84865121178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865121178&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2012.03.008
DO - 10.1016/j.ejca.2012.03.008
M3 - Article
C2 - 22483323
AN - SCOPUS:84865121178
VL - 13
SP - 1947
EP - 1956
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 48
ER -