Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database

Carlos A. Garcia-Etienne, Mariano Tomatis, Joerg Heil, Kay Friedrichs, Rolf Kreienberg, Andreas Denk, Marion Kiechle, Fatemeh Lorenz-Salehi, Rainer Kimmig, Günter Emons, Mahmoud Danaei, Volker Heyl, Uwe Heindrichs, Christoph J. Rageth, Wolfgang Janni, Lorenza Marotti, Marco Rosselli Del Turco, Antonio Ponti, Luigi Cataliotti, Elisabetta CretellaPeter Van Dam, Adelgund Emons, Thomas Gyr, Rita Hils, Peter Kern, Uwe Koehler, Sherko Kuemmel, Doris Liedtke, Alberto Luini, Volker Moebus, Monika Neumann, Stefan Paepke, Olivia Pagani, Lorenzo Pavesi, Dimitri Sarlos, Tim Schlotfeldt, Cristof Sohn, Angela Spelsberg, Gracienne Staelens, Mario Taffurelli, Corrado Tinterri, Iris B. Vergin, Thomas Zemmler, Dominik Wagner, eusomaDB Working Group

Research output: Contribution to journalArticle

Abstract

Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.

Original languageEnglish
Pages (from-to)1947-1956
Number of pages10
JournalEuropean Journal of Cancer
Volume13
Issue number48
DOIs
Publication statusPublished - 2012

    Fingerprint

Keywords

  • Breast surgery
  • Breast surgery in europe
  • Mastectomies
  • Mastectomy
  • Mastectomy rates
  • Mastectomy trends
  • Rates in europe
  • Surgery for breast cancer
  • Surgery trends in europe
  • Trends in europe

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Garcia-Etienne, C. A., Tomatis, M., Heil, J., Friedrichs, K., Kreienberg, R., Denk, A., Kiechle, M., Lorenz-Salehi, F., Kimmig, R., Emons, G., Danaei, M., Heyl, V., Heindrichs, U., Rageth, C. J., Janni, W., Marotti, L., Del Turco, M. R., Ponti, A., Cataliotti, L., ... eusomaDB Working Group (2012). Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database. European Journal of Cancer, 13(48), 1947-1956. https://doi.org/10.1016/j.ejca.2012.03.008