Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database

Carlos A. Garcia-Etienne, Mariano Tomatis, Joerg Heil, Kay Friedrichs, Rolf Kreienberg, Andreas Denk, Marion Kiechle, Fatemeh Lorenz-Salehi, Rainer Kimmig, Günter Emons, Mahmoud Danaei, Volker Heyl, Uwe Heindrichs, Christoph J. Rageth, Wolfgang Janni, Lorenza Marotti, Marco Rosselli Del Turco, Antonio Ponti, Luigi Cataliotti, Elisabetta CretellaPeter Van Dam, Adelgund Emons, Thomas Gyr, Rita Hils, Peter Kern, Uwe Koehler, Sherko Kuemmel, Doris Liedtke, Alberto Luini, Volker Moebus, Monika Neumann, Stefan Paepke, Olivia Pagani, Lorenzo Pavesi, Dimitri Sarlos, Tim Schlotfeldt, Cristof Sohn, Angela Spelsberg, Gracienne Staelens, Mario Taffurelli, Corrado Tinterri, Iris B. Vergin, Thomas Zemmler, Dominik Wagner, eusomaDB Working Group

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.

Original languageEnglish
Pages (from-to)1947-1956
Number of pages10
JournalEuropean Journal of Cancer
Volume13
Issue number48
DOIs
Publication statusPublished - 2012

Fingerprint

Mastectomy
Databases
Breast Neoplasms
Breast
Segmental Mastectomy
Information Storage and Retrieval
Progesterone Receptors
Histology
Population
Neoplasms

Keywords

  • Breast surgery
  • Breast surgery in europe
  • Mastectomies
  • Mastectomy
  • Mastectomy rates
  • Mastectomy trends
  • Rates in europe
  • Surgery for breast cancer
  • Surgery trends in europe
  • Trends in europe

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Garcia-Etienne, C. A., Tomatis, M., Heil, J., Friedrichs, K., Kreienberg, R., Denk, A., ... eusomaDB Working Group (2012). Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database. European Journal of Cancer, 13(48), 1947-1956. https://doi.org/10.1016/j.ejca.2012.03.008

Mastectomy trends for early-stage breast cancer : A report from the EUSOMA multi-institutional European database. / Garcia-Etienne, Carlos A.; Tomatis, Mariano; Heil, Joerg; Friedrichs, Kay; Kreienberg, Rolf; Denk, Andreas; Kiechle, Marion; Lorenz-Salehi, Fatemeh; Kimmig, Rainer; Emons, Günter; Danaei, Mahmoud; Heyl, Volker; Heindrichs, Uwe; Rageth, Christoph J.; Janni, Wolfgang; Marotti, Lorenza; Del Turco, Marco Rosselli; Ponti, Antonio; Cataliotti, Luigi; Cretella, Elisabetta; Van Dam, Peter; Emons, Adelgund; Gyr, Thomas; Hils, Rita; Kern, Peter; Koehler, Uwe; Kuemmel, Sherko; Liedtke, Doris; Luini, Alberto; Moebus, Volker; Neumann, Monika; Paepke, Stefan; Pagani, Olivia; Pavesi, Lorenzo; Sarlos, Dimitri; Schlotfeldt, Tim; Sohn, Cristof; Spelsberg, Angela; Staelens, Gracienne; Taffurelli, Mario; Tinterri, Corrado; Vergin, Iris B.; Zemmler, Thomas; Wagner, Dominik; eusomaDB Working Group.

In: European Journal of Cancer, Vol. 13, No. 48, 2012, p. 1947-1956.

Research output: Contribution to journalArticle

Garcia-Etienne, CA, Tomatis, M, Heil, J, Friedrichs, K, Kreienberg, R, Denk, A, Kiechle, M, Lorenz-Salehi, F, Kimmig, R, Emons, G, Danaei, M, Heyl, V, Heindrichs, U, Rageth, CJ, Janni, W, Marotti, L, Del Turco, MR, Ponti, A, Cataliotti, L, Cretella, E, Van Dam, P, Emons, A, Gyr, T, Hils, R, Kern, P, Koehler, U, Kuemmel, S, Liedtke, D, Luini, A, Moebus, V, Neumann, M, Paepke, S, Pagani, O, Pavesi, L, Sarlos, D, Schlotfeldt, T, Sohn, C, Spelsberg, A, Staelens, G, Taffurelli, M, Tinterri, C, Vergin, IB, Zemmler, T, Wagner, D & eusomaDB Working Group 2012, 'Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database', European Journal of Cancer, vol. 13, no. 48, pp. 1947-1956. https://doi.org/10.1016/j.ejca.2012.03.008
Garcia-Etienne, Carlos A. ; Tomatis, Mariano ; Heil, Joerg ; Friedrichs, Kay ; Kreienberg, Rolf ; Denk, Andreas ; Kiechle, Marion ; Lorenz-Salehi, Fatemeh ; Kimmig, Rainer ; Emons, Günter ; Danaei, Mahmoud ; Heyl, Volker ; Heindrichs, Uwe ; Rageth, Christoph J. ; Janni, Wolfgang ; Marotti, Lorenza ; Del Turco, Marco Rosselli ; Ponti, Antonio ; Cataliotti, Luigi ; Cretella, Elisabetta ; Van Dam, Peter ; Emons, Adelgund ; Gyr, Thomas ; Hils, Rita ; Kern, Peter ; Koehler, Uwe ; Kuemmel, Sherko ; Liedtke, Doris ; Luini, Alberto ; Moebus, Volker ; Neumann, Monika ; Paepke, Stefan ; Pagani, Olivia ; Pavesi, Lorenzo ; Sarlos, Dimitri ; Schlotfeldt, Tim ; Sohn, Cristof ; Spelsberg, Angela ; Staelens, Gracienne ; Taffurelli, Mario ; Tinterri, Corrado ; Vergin, Iris B. ; Zemmler, Thomas ; Wagner, Dominik ; eusomaDB Working Group. / Mastectomy trends for early-stage breast cancer : A report from the EUSOMA multi-institutional European database. In: European Journal of Cancer. 2012 ; Vol. 13, No. 48. pp. 1947-1956.
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title = "Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database",
abstract = "Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3{\%}). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24{\%} per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.",
keywords = "Breast surgery, Breast surgery in europe, Mastectomies, Mastectomy, Mastectomy rates, Mastectomy trends, Rates in europe, Surgery for breast cancer, Surgery trends in europe, Trends in europe",
author = "Garcia-Etienne, {Carlos A.} and Mariano Tomatis and Joerg Heil and Kay Friedrichs and Rolf Kreienberg and Andreas Denk and Marion Kiechle and Fatemeh Lorenz-Salehi and Rainer Kimmig and G{\"u}nter Emons and Mahmoud Danaei and Volker Heyl and Uwe Heindrichs and Rageth, {Christoph J.} and Wolfgang Janni and Lorenza Marotti and {Del Turco}, {Marco Rosselli} and Antonio Ponti and Luigi Cataliotti and Elisabetta Cretella and {Van Dam}, Peter and Adelgund Emons and Thomas Gyr and Rita Hils and Peter Kern and Uwe Koehler and Sherko Kuemmel and Doris Liedtke and Alberto Luini and Volker Moebus and Monika Neumann and Stefan Paepke and Olivia Pagani and Lorenzo Pavesi and Dimitri Sarlos and Tim Schlotfeldt and Cristof Sohn and Angela Spelsberg and Gracienne Staelens and Mario Taffurelli and Corrado Tinterri and Vergin, {Iris B.} and Thomas Zemmler and Dominik Wagner and {eusomaDB Working Group}",
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T1 - Mastectomy trends for early-stage breast cancer

T2 - A report from the EUSOMA multi-institutional European database

AU - Garcia-Etienne, Carlos A.

AU - Tomatis, Mariano

AU - Heil, Joerg

AU - Friedrichs, Kay

AU - Kreienberg, Rolf

AU - Denk, Andreas

AU - Kiechle, Marion

AU - Lorenz-Salehi, Fatemeh

AU - Kimmig, Rainer

AU - Emons, Günter

AU - Danaei, Mahmoud

AU - Heyl, Volker

AU - Heindrichs, Uwe

AU - Rageth, Christoph J.

AU - Janni, Wolfgang

AU - Marotti, Lorenza

AU - Del Turco, Marco Rosselli

AU - Ponti, Antonio

AU - Cataliotti, Luigi

AU - Cretella, Elisabetta

AU - Van Dam, Peter

AU - Emons, Adelgund

AU - Gyr, Thomas

AU - Hils, Rita

AU - Kern, Peter

AU - Koehler, Uwe

AU - Kuemmel, Sherko

AU - Liedtke, Doris

AU - Luini, Alberto

AU - Moebus, Volker

AU - Neumann, Monika

AU - Paepke, Stefan

AU - Pagani, Olivia

AU - Pavesi, Lorenzo

AU - Sarlos, Dimitri

AU - Schlotfeldt, Tim

AU - Sohn, Cristof

AU - Spelsberg, Angela

AU - Staelens, Gracienne

AU - Taffurelli, Mario

AU - Tinterri, Corrado

AU - Vergin, Iris B.

AU - Zemmler, Thomas

AU - Wagner, Dominik

AU - eusomaDB Working Group

PY - 2012

Y1 - 2012

N2 - Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.

AB - Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.

KW - Breast surgery

KW - Breast surgery in europe

KW - Mastectomies

KW - Mastectomy

KW - Mastectomy rates

KW - Mastectomy trends

KW - Rates in europe

KW - Surgery for breast cancer

KW - Surgery trends in europe

KW - Trends in europe

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VL - 13

SP - 1947

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JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

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