Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia

Fausta Beneventi, Elena Locatelli, Mara De Amici, Chiara Cavagnoli, Camilla Bellingeri, Irene De Maggio, Beatrice Ruspini, Arsenio Spinillo

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1 Citation (Scopus)

Abstract

Objectives: To evaluate maternal and fetal Leptin and IL33 concentrations in pregnancy complicated by obesity and preeclampsia. Study design: A case-control study including 35 subjects with obesity (18 normotensive and 17 preeclamptic) and 47 normal weight controls (42 normotensive and 5 preeclamptic). Main outcome measures: Leptin and IL33 concentrations in maternal serum during pregnancy and in cord blood; uterine artery and umbilical artery Doppler velocimetry. Results: Subjects with obesity who developed preeclampsia had higher first trimester maternal (41.5, interquartile range (IQR) = 15.7–65.1 ng/ml) Leptin concentrations compared to either normal weight with (25, IQR = 20.4–25.8 ng/ml) and without hypertension (14.26, IQR = 8.2–22.8) (p <.05) or normotensive subjects with obesity (30.3, IQR = 10.4–38.4) (p <.05). Subjects with obesity who developed preeclampsia (2.4, IQR = 1.7–3.2 pg/ml) or not (1.4, IQR = 0.8–2 pg/ml) had lower first trimester maternal IL33 levels when compared to controls without hypertension (4.8, IQR = 2.9–5.9 pg/ml) (p <.001). Cord blood Leptin and IL33 concentrations were significantly correlated to third trimester maternal concentrations (Spearman rho = 0.51, p <.001 and Spearman rho = 0.68, p <.001, respectively). Uterine artery pulsatility index (PI) were significantly and directly correlated with maternal Leptin levels (p <.002) and inversely and statistically correlated with maternal IL33 concentrations (p <.001). Conclusions: Compared to lean controls, pregnant subjects with obesity had higher serum Leptin and lower IL33 concentrations at first trimester and during pregnancy. This difference persisted also for those who later developed preeclampsia. The relationship between maternal serum levels of Leptin and IL33 with uterine artery Doppler pulsatility index strongly suggests a role of these two markers in early placentation.

Original languageEnglish
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
Publication statusPublished - Jan 1 2019

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Leptin
Pre-Eclampsia
Obesity
Mothers
Pregnancy
Uterine Artery
First Pregnancy Trimester
Fetal Blood
Serum
Hypertension
Weights and Measures
Placentation
Umbilical Arteries
Interleukin-33
Rheology
Third Pregnancy Trimester
Case-Control Studies
Outcome Assessment (Health Care)

Keywords

  • IL33
  • Leptin
  • obesity
  • pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

@article{22c2dbb0283c4040827d7bde64b22e27,
title = "Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia",
abstract = "Objectives: To evaluate maternal and fetal Leptin and IL33 concentrations in pregnancy complicated by obesity and preeclampsia. Study design: A case-control study including 35 subjects with obesity (18 normotensive and 17 preeclamptic) and 47 normal weight controls (42 normotensive and 5 preeclamptic). Main outcome measures: Leptin and IL33 concentrations in maternal serum during pregnancy and in cord blood; uterine artery and umbilical artery Doppler velocimetry. Results: Subjects with obesity who developed preeclampsia had higher first trimester maternal (41.5, interquartile range (IQR) = 15.7–65.1 ng/ml) Leptin concentrations compared to either normal weight with (25, IQR = 20.4–25.8 ng/ml) and without hypertension (14.26, IQR = 8.2–22.8) (p <.05) or normotensive subjects with obesity (30.3, IQR = 10.4–38.4) (p <.05). Subjects with obesity who developed preeclampsia (2.4, IQR = 1.7–3.2 pg/ml) or not (1.4, IQR = 0.8–2 pg/ml) had lower first trimester maternal IL33 levels when compared to controls without hypertension (4.8, IQR = 2.9–5.9 pg/ml) (p <.001). Cord blood Leptin and IL33 concentrations were significantly correlated to third trimester maternal concentrations (Spearman rho = 0.51, p <.001 and Spearman rho = 0.68, p <.001, respectively). Uterine artery pulsatility index (PI) were significantly and directly correlated with maternal Leptin levels (p <.002) and inversely and statistically correlated with maternal IL33 concentrations (p <.001). Conclusions: Compared to lean controls, pregnant subjects with obesity had higher serum Leptin and lower IL33 concentrations at first trimester and during pregnancy. This difference persisted also for those who later developed preeclampsia. The relationship between maternal serum levels of Leptin and IL33 with uterine artery Doppler pulsatility index strongly suggests a role of these two markers in early placentation.",
keywords = "IL33, Leptin, obesity, pregnancy",
author = "Fausta Beneventi and Elena Locatelli and {De Amici}, Mara and Chiara Cavagnoli and Camilla Bellingeri and {De Maggio}, Irene and Beatrice Ruspini and Arsenio Spinillo",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/14767058.2019.1593359",
language = "English",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",

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TY - JOUR

T1 - Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia

AU - Beneventi, Fausta

AU - Locatelli, Elena

AU - De Amici, Mara

AU - Cavagnoli, Chiara

AU - Bellingeri, Camilla

AU - De Maggio, Irene

AU - Ruspini, Beatrice

AU - Spinillo, Arsenio

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To evaluate maternal and fetal Leptin and IL33 concentrations in pregnancy complicated by obesity and preeclampsia. Study design: A case-control study including 35 subjects with obesity (18 normotensive and 17 preeclamptic) and 47 normal weight controls (42 normotensive and 5 preeclamptic). Main outcome measures: Leptin and IL33 concentrations in maternal serum during pregnancy and in cord blood; uterine artery and umbilical artery Doppler velocimetry. Results: Subjects with obesity who developed preeclampsia had higher first trimester maternal (41.5, interquartile range (IQR) = 15.7–65.1 ng/ml) Leptin concentrations compared to either normal weight with (25, IQR = 20.4–25.8 ng/ml) and without hypertension (14.26, IQR = 8.2–22.8) (p <.05) or normotensive subjects with obesity (30.3, IQR = 10.4–38.4) (p <.05). Subjects with obesity who developed preeclampsia (2.4, IQR = 1.7–3.2 pg/ml) or not (1.4, IQR = 0.8–2 pg/ml) had lower first trimester maternal IL33 levels when compared to controls without hypertension (4.8, IQR = 2.9–5.9 pg/ml) (p <.001). Cord blood Leptin and IL33 concentrations were significantly correlated to third trimester maternal concentrations (Spearman rho = 0.51, p <.001 and Spearman rho = 0.68, p <.001, respectively). Uterine artery pulsatility index (PI) were significantly and directly correlated with maternal Leptin levels (p <.002) and inversely and statistically correlated with maternal IL33 concentrations (p <.001). Conclusions: Compared to lean controls, pregnant subjects with obesity had higher serum Leptin and lower IL33 concentrations at first trimester and during pregnancy. This difference persisted also for those who later developed preeclampsia. The relationship between maternal serum levels of Leptin and IL33 with uterine artery Doppler pulsatility index strongly suggests a role of these two markers in early placentation.

AB - Objectives: To evaluate maternal and fetal Leptin and IL33 concentrations in pregnancy complicated by obesity and preeclampsia. Study design: A case-control study including 35 subjects with obesity (18 normotensive and 17 preeclamptic) and 47 normal weight controls (42 normotensive and 5 preeclamptic). Main outcome measures: Leptin and IL33 concentrations in maternal serum during pregnancy and in cord blood; uterine artery and umbilical artery Doppler velocimetry. Results: Subjects with obesity who developed preeclampsia had higher first trimester maternal (41.5, interquartile range (IQR) = 15.7–65.1 ng/ml) Leptin concentrations compared to either normal weight with (25, IQR = 20.4–25.8 ng/ml) and without hypertension (14.26, IQR = 8.2–22.8) (p <.05) or normotensive subjects with obesity (30.3, IQR = 10.4–38.4) (p <.05). Subjects with obesity who developed preeclampsia (2.4, IQR = 1.7–3.2 pg/ml) or not (1.4, IQR = 0.8–2 pg/ml) had lower first trimester maternal IL33 levels when compared to controls without hypertension (4.8, IQR = 2.9–5.9 pg/ml) (p <.001). Cord blood Leptin and IL33 concentrations were significantly correlated to third trimester maternal concentrations (Spearman rho = 0.51, p <.001 and Spearman rho = 0.68, p <.001, respectively). Uterine artery pulsatility index (PI) were significantly and directly correlated with maternal Leptin levels (p <.002) and inversely and statistically correlated with maternal IL33 concentrations (p <.001). Conclusions: Compared to lean controls, pregnant subjects with obesity had higher serum Leptin and lower IL33 concentrations at first trimester and during pregnancy. This difference persisted also for those who later developed preeclampsia. The relationship between maternal serum levels of Leptin and IL33 with uterine artery Doppler pulsatility index strongly suggests a role of these two markers in early placentation.

KW - IL33

KW - Leptin

KW - obesity

KW - pregnancy

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