Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy

Iolanda Mazzucchelli, Lidia Decembrino, Francesca Garofoli, Giulia Ruffinazzi, Véronique Ramoni, Mariaeva Romano, Elena Prisco, Elena Locatelli, Chiara Cavagnoli, Margherita Simonetta, Annalisa De Silvestri, Piermichele Paolillo, Arsenio Spinillo, Mauro Stronati

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The increased number of childbearing women with autoimmune diseases leads to a growing interest in studying relationship among maternal disease, therapy, pregnancy and off-spring. The aim of this study was to determine the impact of autoimmune disease on pregnancy and on neonatal outcome, taking into account the maternal treatment and the transplacental autoantibodies passage. Methods: We studied 70 infants born to 70 pregnant women with autoimmune disease attended in Fondazione IRCCS Policlinico San Matteo, Pavia, Italy from June 2005 to June 2012. Maternal and neonatal characteristics were collected and relevant clinical, laboratory, therapeutics, sonographic and electrocardiographic investigations were recorded and analyzed. Results: We observed a high rate of spontaneous abortions in medical history, 29 %, and 18.6 % of preterm births and 22.9 % of low birth weight (<2500 g). Transplacental autoantibodies passage wasn't related to maternal or obstetrical complication, but anti-Ro/SSA positive pregnancies correlated with abnormal fetal heart rate (P = 0.01). Pregnant women on therapy showed an higher incidence of maternal (p = 0.002), obstetric (p = 0.007) complications and an increased rate of intrauterine growth restriction (p = 0.01) than the untreated ones. Conclusions: Autoimmune diseases in pregnancy require to be carefully monitored to ensure the best possible management of mothers, fetuses and newborns due to the high rate of morbidity specially in case of maternal polytherapy and/or anti-Ro/SSA positivity.

Original languageEnglish
JournalBMC Pediatrics
DOIs
Publication statusAccepted/In press - Dec 18 2015

Fingerprint

Italy
Autoimmune Diseases
Pregnant Women
Mothers
Pregnancy
Autoantibodies
Fetal Heart Rate
Premature Birth
Low Birth Weight Infant
Spontaneous Abortion
Therapeutics
Obstetrics
Fetus
Newborn Infant
Morbidity
Incidence
Growth

Keywords

  • Autoimmune disease
  • Maternal and neonatal outcome
  • Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy. / Mazzucchelli, Iolanda; Decembrino, Lidia; Garofoli, Francesca; Ruffinazzi, Giulia; Ramoni, Véronique; Romano, Mariaeva; Prisco, Elena; Locatelli, Elena; Cavagnoli, Chiara; Simonetta, Margherita; De Silvestri, Annalisa; Paolillo, Piermichele; Spinillo, Arsenio; Stronati, Mauro.

In: BMC Pediatrics, 18.12.2015.

Research output: Contribution to journalArticle

Mazzucchelli, Iolanda ; Decembrino, Lidia ; Garofoli, Francesca ; Ruffinazzi, Giulia ; Ramoni, Véronique ; Romano, Mariaeva ; Prisco, Elena ; Locatelli, Elena ; Cavagnoli, Chiara ; Simonetta, Margherita ; De Silvestri, Annalisa ; Paolillo, Piermichele ; Spinillo, Arsenio ; Stronati, Mauro. / Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy. In: BMC Pediatrics. 2015.
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abstract = "Background: The increased number of childbearing women with autoimmune diseases leads to a growing interest in studying relationship among maternal disease, therapy, pregnancy and off-spring. The aim of this study was to determine the impact of autoimmune disease on pregnancy and on neonatal outcome, taking into account the maternal treatment and the transplacental autoantibodies passage. Methods: We studied 70 infants born to 70 pregnant women with autoimmune disease attended in Fondazione IRCCS Policlinico San Matteo, Pavia, Italy from June 2005 to June 2012. Maternal and neonatal characteristics were collected and relevant clinical, laboratory, therapeutics, sonographic and electrocardiographic investigations were recorded and analyzed. Results: We observed a high rate of spontaneous abortions in medical history, 29 {\%}, and 18.6 {\%} of preterm births and 22.9 {\%} of low birth weight (<2500 g). Transplacental autoantibodies passage wasn't related to maternal or obstetrical complication, but anti-Ro/SSA positive pregnancies correlated with abnormal fetal heart rate (P = 0.01). Pregnant women on therapy showed an higher incidence of maternal (p = 0.002), obstetric (p = 0.007) complications and an increased rate of intrauterine growth restriction (p = 0.01) than the untreated ones. Conclusions: Autoimmune diseases in pregnancy require to be carefully monitored to ensure the best possible management of mothers, fetuses and newborns due to the high rate of morbidity specially in case of maternal polytherapy and/or anti-Ro/SSA positivity.",
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AU - Mazzucchelli, Iolanda

AU - Decembrino, Lidia

AU - Garofoli, Francesca

AU - Ruffinazzi, Giulia

AU - Ramoni, Véronique

AU - Romano, Mariaeva

AU - Prisco, Elena

AU - Locatelli, Elena

AU - Cavagnoli, Chiara

AU - Simonetta, Margherita

AU - De Silvestri, Annalisa

AU - Paolillo, Piermichele

AU - Spinillo, Arsenio

AU - Stronati, Mauro

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N2 - Background: The increased number of childbearing women with autoimmune diseases leads to a growing interest in studying relationship among maternal disease, therapy, pregnancy and off-spring. The aim of this study was to determine the impact of autoimmune disease on pregnancy and on neonatal outcome, taking into account the maternal treatment and the transplacental autoantibodies passage. Methods: We studied 70 infants born to 70 pregnant women with autoimmune disease attended in Fondazione IRCCS Policlinico San Matteo, Pavia, Italy from June 2005 to June 2012. Maternal and neonatal characteristics were collected and relevant clinical, laboratory, therapeutics, sonographic and electrocardiographic investigations were recorded and analyzed. Results: We observed a high rate of spontaneous abortions in medical history, 29 %, and 18.6 % of preterm births and 22.9 % of low birth weight (<2500 g). Transplacental autoantibodies passage wasn't related to maternal or obstetrical complication, but anti-Ro/SSA positive pregnancies correlated with abnormal fetal heart rate (P = 0.01). Pregnant women on therapy showed an higher incidence of maternal (p = 0.002), obstetric (p = 0.007) complications and an increased rate of intrauterine growth restriction (p = 0.01) than the untreated ones. Conclusions: Autoimmune diseases in pregnancy require to be carefully monitored to ensure the best possible management of mothers, fetuses and newborns due to the high rate of morbidity specially in case of maternal polytherapy and/or anti-Ro/SSA positivity.

AB - Background: The increased number of childbearing women with autoimmune diseases leads to a growing interest in studying relationship among maternal disease, therapy, pregnancy and off-spring. The aim of this study was to determine the impact of autoimmune disease on pregnancy and on neonatal outcome, taking into account the maternal treatment and the transplacental autoantibodies passage. Methods: We studied 70 infants born to 70 pregnant women with autoimmune disease attended in Fondazione IRCCS Policlinico San Matteo, Pavia, Italy from June 2005 to June 2012. Maternal and neonatal characteristics were collected and relevant clinical, laboratory, therapeutics, sonographic and electrocardiographic investigations were recorded and analyzed. Results: We observed a high rate of spontaneous abortions in medical history, 29 %, and 18.6 % of preterm births and 22.9 % of low birth weight (<2500 g). Transplacental autoantibodies passage wasn't related to maternal or obstetrical complication, but anti-Ro/SSA positive pregnancies correlated with abnormal fetal heart rate (P = 0.01). Pregnant women on therapy showed an higher incidence of maternal (p = 0.002), obstetric (p = 0.007) complications and an increased rate of intrauterine growth restriction (p = 0.01) than the untreated ones. Conclusions: Autoimmune diseases in pregnancy require to be carefully monitored to ensure the best possible management of mothers, fetuses and newborns due to the high rate of morbidity specially in case of maternal polytherapy and/or anti-Ro/SSA positivity.

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