Maternal-conceptus cross talk - A review

Paola Viganò, S. Mangioni, F. Pompei, I. Chiodo

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The implantation process requires a functionally normal conceptus and a receptive endometrium, but also a communication link between them. This paracrine dialogue involves not only gonadal steroids but also a variety of other biologic molecules secreted by the conceptus and the reproductive tissues themselves in a communicative, interconnected network. The factors facilitating this dialogue includes chemokines, cytokines, adhesion molecules, growth factors. Recently, the soluble form of HLA-G and the vitamin D system have also been proposed as components of this cross-talk. Inherent among the factors involved is the fact that their effects are redundant and pleiotropic. Normal implantation and placentation are critical for a successful pregnancy. Therefore, a better understanding of the molecular mechanisms responsible for these processes will lead to the development of new regulating agents with novel diagnostic, biological and therapeutic potential for both facilitating and hindering a normal reproductive function.

Original languageEnglish
JournalPlacenta
Volume24
Issue numberSUPPL. B
DOIs
Publication statusPublished - Oct 2003

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HLA-G Antigens
Placentation
Endometrium
Chemokines
Vitamin D
Intercellular Signaling Peptides and Proteins
Steroids
Mothers
Cytokines
Pregnancy
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Maternal-conceptus cross talk - A review. / Viganò, Paola; Mangioni, S.; Pompei, F.; Chiodo, I.

In: Placenta, Vol. 24, No. SUPPL. B, 10.2003.

Research output: Contribution to journalArticle

Viganò, P, Mangioni, S, Pompei, F & Chiodo, I 2003, 'Maternal-conceptus cross talk - A review', Placenta, vol. 24, no. SUPPL. B. https://doi.org/10.1016/S0143-4004(03)00137-1
Viganò, Paola ; Mangioni, S. ; Pompei, F. ; Chiodo, I. / Maternal-conceptus cross talk - A review. In: Placenta. 2003 ; Vol. 24, No. SUPPL. B.
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