Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

Cristina O’Callaghan-Gordo, Manolis Kogevinas, Marie Pedersen, Eleni Fthenou, Ana Espinosa, Xristina Tsiapa, Georgia Chalkiadaki, Vasiliki Daraki, Eirini Dermitzaki, Ilse Decordier, Peter B. Farmer, Panagiotis Georgiadis, Vaggelis Georgiou, Soterios A. Kyrtopoulos, Domenico Franco Merlo, Dora Romaguera, Theano Roumeliotaki, Katerina Sarri, Margareta Törnqvist, Kim Vande LoockHans von Stedingk, Jos Kleinjans, Micheline Kirsch-Volders, Leda Chatzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults. Methods: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO). Results: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge. Conclusions: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalEuropean Journal of Nutrition
DOIs
Publication statusAccepted/In press - Sep 21 2016

Fingerprint

Rheiformes
Greece
Mothers
Newborn Infant
Diet
T-Lymphocytes
Pregnancy
Neoplasms
Biomarkers
Guidelines
Maternal Exposure
DNA Adducts
Tumor Biomarkers
Fetal Blood
insulin receptor-related receptor
Pregnant Women
Hemoglobins
Interviews
Exercise
Food

Keywords

  • Cancer
  • Diet
  • Epidemiology
  • Genotoxicity
  • Maternal nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

O’Callaghan-Gordo, C., Kogevinas, M., Pedersen, M., Fthenou, E., Espinosa, A., Tsiapa, X., ... Chatzi, L. (Accepted/In press). Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). European Journal of Nutrition, 1-10. https://doi.org/10.1007/s00394-016-1310-1

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). / O’Callaghan-Gordo, Cristina; Kogevinas, Manolis; Pedersen, Marie; Fthenou, Eleni; Espinosa, Ana; Tsiapa, Xristina; Chalkiadaki, Georgia; Daraki, Vasiliki; Dermitzaki, Eirini; Decordier, Ilse; Farmer, Peter B.; Georgiadis, Panagiotis; Georgiou, Vaggelis; Kyrtopoulos, Soterios A.; Merlo, Domenico Franco; Romaguera, Dora; Roumeliotaki, Theano; Sarri, Katerina; Törnqvist, Margareta; Loock, Kim Vande; von Stedingk, Hans; Kleinjans, Jos; Kirsch-Volders, Micheline; Chatzi, Leda.

In: European Journal of Nutrition, 21.09.2016, p. 1-10.

Research output: Contribution to journalArticle

O’Callaghan-Gordo, C, Kogevinas, M, Pedersen, M, Fthenou, E, Espinosa, A, Tsiapa, X, Chalkiadaki, G, Daraki, V, Dermitzaki, E, Decordier, I, Farmer, PB, Georgiadis, P, Georgiou, V, Kyrtopoulos, SA, Merlo, DF, Romaguera, D, Roumeliotaki, T, Sarri, K, Törnqvist, M, Loock, KV, von Stedingk, H, Kleinjans, J, Kirsch-Volders, M & Chatzi, L 2016, 'Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)', European Journal of Nutrition, pp. 1-10. https://doi.org/10.1007/s00394-016-1310-1
O’Callaghan-Gordo, Cristina ; Kogevinas, Manolis ; Pedersen, Marie ; Fthenou, Eleni ; Espinosa, Ana ; Tsiapa, Xristina ; Chalkiadaki, Georgia ; Daraki, Vasiliki ; Dermitzaki, Eirini ; Decordier, Ilse ; Farmer, Peter B. ; Georgiadis, Panagiotis ; Georgiou, Vaggelis ; Kyrtopoulos, Soterios A. ; Merlo, Domenico Franco ; Romaguera, Dora ; Roumeliotaki, Theano ; Sarri, Katerina ; Törnqvist, Margareta ; Loock, Kim Vande ; von Stedingk, Hans ; Kleinjans, Jos ; Kirsch-Volders, Micheline ; Chatzi, Leda. / Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). In: European Journal of Nutrition. 2016 ; pp. 1-10.
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abstract = "Purpose: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults. Methods: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO). Results: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge. Conclusions: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.",
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T1 - Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

AU - O’Callaghan-Gordo, Cristina

AU - Kogevinas, Manolis

AU - Pedersen, Marie

AU - Fthenou, Eleni

AU - Espinosa, Ana

AU - Tsiapa, Xristina

AU - Chalkiadaki, Georgia

AU - Daraki, Vasiliki

AU - Dermitzaki, Eirini

AU - Decordier, Ilse

AU - Farmer, Peter B.

AU - Georgiadis, Panagiotis

AU - Georgiou, Vaggelis

AU - Kyrtopoulos, Soterios A.

AU - Merlo, Domenico Franco

AU - Romaguera, Dora

AU - Roumeliotaki, Theano

AU - Sarri, Katerina

AU - Törnqvist, Margareta

AU - Loock, Kim Vande

AU - von Stedingk, Hans

AU - Kleinjans, Jos

AU - Kirsch-Volders, Micheline

AU - Chatzi, Leda

PY - 2016/9/21

Y1 - 2016/9/21

N2 - Purpose: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults. Methods: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO). Results: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge. Conclusions: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

AB - Purpose: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults. Methods: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO). Results: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge. Conclusions: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

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KW - Diet

KW - Epidemiology

KW - Genotoxicity

KW - Maternal nutrition

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