Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris)

Eleni Papadopoulou, Manolis Kogevinas, Maria Botsivali, Marie Pedersen, Harrie Besselink, Michelle A. Mendez, Sarah Fleming, Laura J. Hardie, Lisbeth E. Knudsen, John Wright, Silvia Agramunt, Jordi Sunyer, Berit Granum, Kristine B. Gutzkow, Gunnar Brunborg, Jan Alexander, Helle Margrete Meltzer, Anne Lise Brantsæter, Katerina Sarri, Leda ChatziDomenico F. Merlo, Jos C. Kleinjans, Margaretha Haugen

Research output: Contribution to journalArticle

Abstract

Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX®) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of - 121. g (95% confidence intervals: - 232, - 10. g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (- 1.4. days, 95% CI: - 3.8, 1.0. days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalScience of the Total Environment
Volume484
Issue number1
DOIs
Publication statusPublished - Jun 15 2014

Fingerprint

Dioxins
Nutrition
dioxin
Mothers
Parturition
diet
Diet
Oils and fats
Luciferases
Birth Weight
Plasmas
Cheeses
Fats
Dairies
exposure
Meats
Bioassay
Organic pollutants
fat
Nutrition Policy

Keywords

  • Birth weight
  • Cohort study
  • Dietary patterns
  • Dioxins
  • DR-CALUX
  • Pregnancy

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering
  • Medicine(all)

Cite this

Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris). / Papadopoulou, Eleni; Kogevinas, Manolis; Botsivali, Maria; Pedersen, Marie; Besselink, Harrie; Mendez, Michelle A.; Fleming, Sarah; Hardie, Laura J.; Knudsen, Lisbeth E.; Wright, John; Agramunt, Silvia; Sunyer, Jordi; Granum, Berit; Gutzkow, Kristine B.; Brunborg, Gunnar; Alexander, Jan; Meltzer, Helle Margrete; Brantsæter, Anne Lise; Sarri, Katerina; Chatzi, Leda; Merlo, Domenico F.; Kleinjans, Jos C.; Haugen, Margaretha.

In: Science of the Total Environment, Vol. 484, No. 1, 15.06.2014, p. 121-128.

Research output: Contribution to journalArticle

Papadopoulou, E, Kogevinas, M, Botsivali, M, Pedersen, M, Besselink, H, Mendez, MA, Fleming, S, Hardie, LJ, Knudsen, LE, Wright, J, Agramunt, S, Sunyer, J, Granum, B, Gutzkow, KB, Brunborg, G, Alexander, J, Meltzer, HM, Brantsæter, AL, Sarri, K, Chatzi, L, Merlo, DF, Kleinjans, JC & Haugen, M 2014, 'Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris)', Science of the Total Environment, vol. 484, no. 1, pp. 121-128. https://doi.org/10.1016/j.scitotenv.2014.03.047
Papadopoulou, Eleni ; Kogevinas, Manolis ; Botsivali, Maria ; Pedersen, Marie ; Besselink, Harrie ; Mendez, Michelle A. ; Fleming, Sarah ; Hardie, Laura J. ; Knudsen, Lisbeth E. ; Wright, John ; Agramunt, Silvia ; Sunyer, Jordi ; Granum, Berit ; Gutzkow, Kristine B. ; Brunborg, Gunnar ; Alexander, Jan ; Meltzer, Helle Margrete ; Brantsæter, Anne Lise ; Sarri, Katerina ; Chatzi, Leda ; Merlo, Domenico F. ; Kleinjans, Jos C. ; Haugen, Margaretha. / Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris). In: Science of the Total Environment. 2014 ; Vol. 484, No. 1. pp. 121-128.
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AU - Fleming, Sarah

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AU - Knudsen, Lisbeth E.

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