Maternal dietary exposure to low-dose bisphenol a affects metabolic and signaling pathways in the brain of rat fetuses

Claudia Tonini, Marco Segatto, Simone Gagliardi, Simona Bertoli, Alessandro Leone, Laura Barberio, Maurizio Mandalà, Valentina Pallottini

Research output: Contribution to journalArticlepeer-review

Abstract

BisphenolA(BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. BPA exposure is widespread and more than 90% of individuals have detectable amounts of the molecule in their body fluids, which originates primarily from diet. Here, we investigated whether prenatal exposure to BPA affects the mevalonate (MVA) pathway in rat brain fetuses, and whether potential effects are sex-dependent. The MVA pathway is important for brain development and function. Our results demonstrate that the fetal brain, exposed in utero to a very low dose of BPA (2.5 µg/kg/day), displayed altered MVA pathway activation, increased protein prenylation, and a decreased level of pro-BDNF. Interestingly, the BPA-induced effects on estrogen receptor ff were sex-dependent. In conclusion, this work demonstrates intergenerational effects of BPA on the brain at very low doses. Our results reveal new targets for BPA-induced interference and underline the impacts of BPA on health.

Original languageEnglish
Article number1448
JournalNutrients
Volume12
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • 3-hydroxy 3-methylglutaryl coenzymeareductase
  • Bisphenol a
  • Cholesterol
  • Mevalonate pathway
  • Neurotrophins

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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