@article{2816b17be8ce48729c152461e7fa73f1,
title = "Maternal dietary exposure to low-dose bisphenol a affects metabolic and signaling pathways in the brain of rat fetuses",
abstract = "BisphenolA(BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. BPA exposure is widespread and more than 90% of individuals have detectable amounts of the molecule in their body fluids, which originates primarily from diet. Here, we investigated whether prenatal exposure to BPA affects the mevalonate (MVA) pathway in rat brain fetuses, and whether potential effects are sex-dependent. The MVA pathway is important for brain development and function. Our results demonstrate that the fetal brain, exposed in utero to a very low dose of BPA (2.5 µg/kg/day), displayed altered MVA pathway activation, increased protein prenylation, and a decreased level of pro-BDNF. Interestingly, the BPA-induced effects on estrogen receptor ff were sex-dependent. In conclusion, this work demonstrates intergenerational effects of BPA on the brain at very low doses. Our results reveal new targets for BPA-induced interference and underline the impacts of BPA on health.",
keywords = "3-hydroxy 3-methylglutaryl coenzymeareductase, Bisphenol a, Cholesterol, Mevalonate pathway, Neurotrophins",
author = "Claudia Tonini and Marco Segatto and Simone Gagliardi and Simona Bertoli and Alessandro Leone and Laura Barberio and Maurizio Mandal{\`a} and Valentina Pallottini",
note = "Funding Information: AAuutthhoorrCCoonnttrriibbuuttiioonnss:: CCoonncceeppttuuaalliizzaattioionn,,VV.P..P; .S; .BS..B; M.; M.M.M.; f.o; rfmoraml aanl aalnyasliys,sVis.,P .Va.nPd. aCn.dT .;Ci.nTv.;e sintivgeastitoigna,tCio.Tn.,; CA..TL..;; A.L.; L.B.; S.G.; resources, V.P.; S.B.; M.M.; data curation, V.P.; M.S.; C.T.; writing—original draft preparation, C.T.; writing—review and editing, C.T.; V.P.; M.S.; project administration, V.P.; funding acquisition, V.P.; S.B.; authors have read and agreed to the published version of the manuscript. M.M.; All authors have read and agreed to the published version of the manuscript. Funding: This research was funded by PRIN-MIUR, Contract grant number: 2015SHM58M_004 to VP; 2015SHM58M_003 to S.B; and 2015SHM58M_005 to M.M.; Departments of Excellence 2017—legge 232/2016—art.1, c2o0m15mSHi M31548–M33_700a3w taor dSe.Bd; taondD e2p0t1.5SoHf MSc5ie8nMce_—00U5 ntoiv Mer.sMit.y; DRoepmaartTmreen—tsR oofm Eex—ceIltlaelnycefo2r021071—8–le2g0g2e2 ;2M32i/n2i0s1t6e—ro art.1, commi 314–337 awarded to Dept. of Science—University Roma Tre—Rome—Italy for 2018–2022; Ministero Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = may,
doi = "10.3390/nu12051448",
language = "English",
volume = "12",
journal = "Nutrients",
issn = "2072-6643",
publisher = "NLM (Medline)",
number = "5",
}