Maternal exposure to particulate air pollution and term birth weight: A multi-country evaluation of effect and heterogeneity

Payam Dadvand, Jennifer Parker, Michelle L. Bell, Matteo Bonzini, Michael Brauer, Lyndsey A. Darrow, Ulrike Gehring, Svetlana V. Glinianaia, Nelson Gouveia, Eun Hee Ha, Jong Han Leem, Edith H. van den Hooven, Bin Jalaludin, Bill M. Jesdale, Johanna Lepeule, Rachel Morello-Frosch, Geoffrey G. Morgan, Angela Cecilia Pesatori, Frank H. Pierik, Tanja Pless-MulloliDavid Q. Rich, Sheela Sathyanarayana, Juhee Seo, Rémy Slama, Matthew Strickland, Lillian Tamburic, Daniel Wartenberg, Mark J. Nieuwenhuijsen, Tracey J. Woodruff

Research output: Contribution to journalArticle

Abstract

Background: A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent. Objectives: We aimed to quantify the association between maternal exposure to particulate air pollution and term birth weight and low birth weight (LBW) across 14 centers from 9 countries, and to explore the influence of site characteristics and exposure assessment methods on between-center heterogeneity in this association. Methods: Using a common analytical protocol, International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO) centers generated effect estimates for term LBW and continuous birth weight associated with PM10 and PM2.5 (particulate matter ≤ 10 and 2.5 μm). We used meta-analysis to combine the estimates of effect across centers (~ 3 million births) and used meta-regression to evaluate the influence of center characteristics and exposure assessment methods on between-center heterogeneity in reported effect estimates. Results: In random-effects meta-analyses, term LBW was positively associated with a 10-μg/m3 increase in PM10 [odds ratio (OR) = 1.03; 95% CI: 1.01, 1.05] and PM2.5 (OR = 1.10; 95% CI: 1.03, 1.18) exposure during the entire pregnancy, adjusted for maternal socioeconomic status. A 10-μg/m3 increase in PM10 exposure was also negatively associated with term birth weight as a continuous outcome in the fully adjusted random-effects meta-analyses (-8.9 g; 95% CI: -13.2, -4.6 g). Meta-regressions revealed that centers with higher median PM2.5 levels and PM2.5:PM10 ratios, and centers that used a temporal exposure assessment (compared with spatiotemporal), tended to report stronger associations. Conclusion: Maternal exposure to particulate pollution was associated with LBW at term across study populations. We detected three site characteristics and aspects of exposure assessment methodology that appeared to contribute to the variation in associations reported by centers.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalEnvironmental Health Perspectives
Volume121
Issue number3
DOIs
Publication statusPublished - 2013

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Keywords

  • Air pollution
  • Fetal growth
  • Heterogeneity
  • ICAPPO
  • Low birth weight
  • Meta-analysis
  • Meta-regression
  • Multi-center study
  • Particulate matter
  • Pregnancy

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Dadvand, P., Parker, J., Bell, M. L., Bonzini, M., Brauer, M., Darrow, L. A., Gehring, U., Glinianaia, S. V., Gouveia, N., Ha, E. H., Leem, J. H., van den Hooven, E. H., Jalaludin, B., Jesdale, B. M., Lepeule, J., Morello-Frosch, R., Morgan, G. G., Pesatori, A. C., Pierik, F. H., ... Woodruff, T. J. (2013). Maternal exposure to particulate air pollution and term birth weight: A multi-country evaluation of effect and heterogeneity. Environmental Health Perspectives, 121(3), 367-373. https://doi.org/10.1289/ehp.1205575