TY - JOUR
T1 - Maternal exposure to particulate air pollution and term birth weight
T2 - A multi-country evaluation of effect and heterogeneity
AU - Dadvand, Payam
AU - Parker, Jennifer
AU - Bell, Michelle L.
AU - Bonzini, Matteo
AU - Brauer, Michael
AU - Darrow, Lyndsey A.
AU - Gehring, Ulrike
AU - Glinianaia, Svetlana V.
AU - Gouveia, Nelson
AU - Ha, Eun Hee
AU - Leem, Jong Han
AU - van den Hooven, Edith H.
AU - Jalaludin, Bin
AU - Jesdale, Bill M.
AU - Lepeule, Johanna
AU - Morello-Frosch, Rachel
AU - Morgan, Geoffrey G.
AU - Pesatori, Angela Cecilia
AU - Pierik, Frank H.
AU - Pless-Mulloli, Tanja
AU - Rich, David Q.
AU - Sathyanarayana, Sheela
AU - Seo, Juhee
AU - Slama, Rémy
AU - Strickland, Matthew
AU - Tamburic, Lillian
AU - Wartenberg, Daniel
AU - Nieuwenhuijsen, Mark J.
AU - Woodruff, Tracey J.
PY - 2013
Y1 - 2013
N2 - Background: A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent. Objectives: We aimed to quantify the association between maternal exposure to particulate air pollution and term birth weight and low birth weight (LBW) across 14 centers from 9 countries, and to explore the influence of site characteristics and exposure assessment methods on between-center heterogeneity in this association. Methods: Using a common analytical protocol, International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO) centers generated effect estimates for term LBW and continuous birth weight associated with PM10 and PM2.5 (particulate matter ≤ 10 and 2.5 μm). We used meta-analysis to combine the estimates of effect across centers (~ 3 million births) and used meta-regression to evaluate the influence of center characteristics and exposure assessment methods on between-center heterogeneity in reported effect estimates. Results: In random-effects meta-analyses, term LBW was positively associated with a 10-μg/m3 increase in PM10 [odds ratio (OR) = 1.03; 95% CI: 1.01, 1.05] and PM2.5 (OR = 1.10; 95% CI: 1.03, 1.18) exposure during the entire pregnancy, adjusted for maternal socioeconomic status. A 10-μg/m3 increase in PM10 exposure was also negatively associated with term birth weight as a continuous outcome in the fully adjusted random-effects meta-analyses (-8.9 g; 95% CI: -13.2, -4.6 g). Meta-regressions revealed that centers with higher median PM2.5 levels and PM2.5:PM10 ratios, and centers that used a temporal exposure assessment (compared with spatiotemporal), tended to report stronger associations. Conclusion: Maternal exposure to particulate pollution was associated with LBW at term across study populations. We detected three site characteristics and aspects of exposure assessment methodology that appeared to contribute to the variation in associations reported by centers.
AB - Background: A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent. Objectives: We aimed to quantify the association between maternal exposure to particulate air pollution and term birth weight and low birth weight (LBW) across 14 centers from 9 countries, and to explore the influence of site characteristics and exposure assessment methods on between-center heterogeneity in this association. Methods: Using a common analytical protocol, International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO) centers generated effect estimates for term LBW and continuous birth weight associated with PM10 and PM2.5 (particulate matter ≤ 10 and 2.5 μm). We used meta-analysis to combine the estimates of effect across centers (~ 3 million births) and used meta-regression to evaluate the influence of center characteristics and exposure assessment methods on between-center heterogeneity in reported effect estimates. Results: In random-effects meta-analyses, term LBW was positively associated with a 10-μg/m3 increase in PM10 [odds ratio (OR) = 1.03; 95% CI: 1.01, 1.05] and PM2.5 (OR = 1.10; 95% CI: 1.03, 1.18) exposure during the entire pregnancy, adjusted for maternal socioeconomic status. A 10-μg/m3 increase in PM10 exposure was also negatively associated with term birth weight as a continuous outcome in the fully adjusted random-effects meta-analyses (-8.9 g; 95% CI: -13.2, -4.6 g). Meta-regressions revealed that centers with higher median PM2.5 levels and PM2.5:PM10 ratios, and centers that used a temporal exposure assessment (compared with spatiotemporal), tended to report stronger associations. Conclusion: Maternal exposure to particulate pollution was associated with LBW at term across study populations. We detected three site characteristics and aspects of exposure assessment methodology that appeared to contribute to the variation in associations reported by centers.
KW - Air pollution
KW - Fetal growth
KW - Heterogeneity
KW - ICAPPO
KW - Low birth weight
KW - Meta-analysis
KW - Meta-regression
KW - Multi-center study
KW - Particulate matter
KW - Pregnancy
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UR - http://www.scopus.com/inward/citedby.url?scp=84874624101&partnerID=8YFLogxK
U2 - 10.1289/ehp.1205575
DO - 10.1289/ehp.1205575
M3 - Article
C2 - 23384584
AN - SCOPUS:84874624101
VL - 121
SP - 367
EP - 373
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 3
ER -