Maternal, fetal and neonatal diagnosis of congenital human cytomegalovirus infection

Maria Grazia Revello, Giuseppe Gerna

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The socio-economic burden associated with congenital human cytomegalovirus (HCMV) infection is well recognized. Nevertheless, women are neither informed nor tested for HCMV antibody, and in the absence of screening, HCMV infections proceed mostly undiagnosed during pregnancy. Methods: Knowledge has accumulated concerning both the natural history of HCMV infection and the availability of diagnostic tests. Results: Different assays for the diagnosis in the mother, fetus and newborn are well established. In addition, positive and negative predictive values of different assays for prenatal diagnosis have improved over time. Conclusions: Without an HCMV vaccine, diagnosis of primary infection in the mother and of congenital infection in the fetus/newborn are key factors for management of congenital HCMV infection.

Original languageEnglish
Pages (from-to)547-563
Number of pages17
JournalExpert Opinion on Medical Diagnostics
Volume2
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • Diagnosis
  • Fetus
  • Human cytomegalovirus
  • Infection
  • Newborn
  • Pregnant woman

ASJC Scopus subject areas

  • Molecular Medicine
  • Biomedical Engineering
  • Medicine(all)
  • Biochemistry, medical

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