Maternal, fetal, and neonatal parameters for prognosis and counseling of HCMV congenital infection

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Abstract

To investigate retrospectively the prognostic significance of maternal, fetal, and neonatal parameters and clinical outcome in 150 HCMV congenital infections during the period 1995-2009. HCMV fetal infection was investigated in amniotic fluid and fetal blood samples. HCMV congenital infection was confirmed in newborn urine and blood samples. Symptomatic infection was defined in HCMV-infected fetuses and in infected newborns on the basis of physical and instrumental findings. Follow-up at 3, 6, 12 months, and then annually up to school age, included clinical evaluation, funduscopic, audiologic, neurologic, and cognitive assessment. Overall, 122/150 (81.3%) newborns were asymptomatic and 28/150 (18.7%) were symptomatic at birth. The best prognostic maternal parameter of symptomatic infection at birth was gestational age at infection (P=0.037). The best fetal virological markers were HCMV DNA levels in amniotic fluid (P

Original languageEnglish
Pages (from-to)2163-2170
Number of pages8
JournalJournal of Medical Virology
Volume86
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Congenital infection
  • Cytomegalovirus
  • Maternal, fetal and neonatal predictors of symptoms

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Medicine(all)

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