Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits

Wulf Palinski, Francesco P. D'Armiento, Joseph L. Witztum, Filomena De Nigris, Florencia Casanada, Mario Condorelli, Mercedes Silvestre, Claudio Napoli

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal hypercholesterolemia during pregnancy is associated with enhanced fatty streak formation in human fetuses and faster progression of atherosclerosis during childhood even under normocholesterolemic conditions. A causal role of maternal hypercholesterolemia in lesion formation during fetal development has previously been established in rabbits. The same experimental model is now used to establish that maternal hypercholesterolemia or ensuing pathogenic events in fetal arteries enhance atherogenesis later in life. Five groups of rabbit mothers were fed chow, cholesterol-enriched chow, or cholesterol-enriched chow plus 1000 IU vitamin E, 3% cholestyramine, or both during pregnancy. Offspring of all groups (n= 136) were fed a mildly hypercholesterolemic diet for up to a year and had similar cholesterol levels. Aortic lesion sizes and lipid peroxidation products in plasma and lesions in offspring were determined at birth, 6 months, or 12 months. Lesion progression in offspring of hypercholesterolemic mothers was greater than in all other groups. At each time point, offspring of hypercholesterolemic mothers had 1.5- to 3-fold larger lesions than offspring of normocholesterolemic mothers (P

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalCirculation Research
Volume89
Issue number11
Publication statusPublished - Nov 23 2001

Keywords

  • Cholestyramine
  • Fetus
  • Oxidation
  • Pathogenesis
  • Vitamin E

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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