Maternal hypercholesterolemia enhances atherogenesis in normocholesterolemic rabbits, which is inhibited by antioxidant or lipid-lowering intervention during pregnancy: An experimental model of atherogenic mechanisms in human fetuses

Claudio Napoli, Joseph L. Witztum, Federico Calara, Filomena De Nigris, Wulf Palinski

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal hypercholesterolemia during pregnancy is associated with a marked increase in aortic fatty streak formation in human fetuses and faster progression of atherosclerosis during normocholesterolemic childhood. However, the mechanisms responsible are unknown, and the contribution of genetic differences is difficult to assess in humans. The goal of this study was to determine whether maternal hypercholesterolemia per se may cause enhanced fatty streak formation in offspring and whether interventions during pregnancy can reduce it. During pregnancy, 1 group of New Zealand White rabbits was fed control chow and 8 groups were fed hypercholesterolemic diets Chol 1 (yielding plasma cholesterol of 153 mg/dL) or Chol 2 (yielding 359 mg/dL) without or with cholestyramine, vitamin E, or both. Offspring (n = 15 to 25 per group) were killed at birth. Maternal hypercholesterolemia enhanced mean lesion size in the aorta of their offspring at birth from 44 ± 18 x 103 μm2 per section in controls to 85 ± 26 x 103 in Chol 1 and 156 ± 49 x 103 in Chol 2 groups (P

Original languageEnglish
Pages (from-to)946-952
Number of pages7
JournalCirculation Research
Volume87
Issue number10
Publication statusPublished - Nov 10 2000

Keywords

  • Atherosclerosis
  • Cholestyramine
  • Oxidation
  • Prevention
  • Vitamin E

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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