Abstract
Fetal overgrowth and higher adiposity are hallmarks of pregnancy with maternal obesity and poor glucose tolerance, two conditions associated with decreased maternal insulin sensitivity. In non-pregnant individuals, adipokines, vasoactive peptides, and components of the immune system crosstalk with metabolic factors to generate signals triggering obesity and impaired insulin action. We have investigated circulating maternal and fetal cytokines and growth-factors as potential biochemical markers of fetal adiposity. Mothers and neonates were classified into three tertiles (T1-T3) using total neonatal fat mass as the outcome with 309 ± 25 g in T1, 478 ± 40 g in T2, and 529 ± 39 g in T3. Umbilical cord endothelin-1 (ET-1), C-peptide, and leptin were higher in T3 and T2 versus T1. Only cord leptin was strongly associated with fetal fat mass (P
| Original language | English |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | Journal of the Society for Gynecologic Investigation |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2006 |
Fingerprint
Keywords
- Cytokines
- Fetal adiposity
- Growth factors
- Obesity
- Pregnancy
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Maternal interleukin-6 : Marker of fetal growth and adiposity. / Radaelli, Tatjana; Uvena-Celebrezze, Jennifer; Minium, Judi; Huston-Presley, Larraine; Catalano, Patrick; Hauguel-de Mouzon, Sylvie.
In: Journal of the Society for Gynecologic Investigation, Vol. 13, No. 1, 01.2006, p. 53-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maternal interleukin-6
T2 - Marker of fetal growth and adiposity
AU - Radaelli, Tatjana
AU - Uvena-Celebrezze, Jennifer
AU - Minium, Judi
AU - Huston-Presley, Larraine
AU - Catalano, Patrick
AU - Hauguel-de Mouzon, Sylvie
PY - 2006/1
Y1 - 2006/1
N2 - Fetal overgrowth and higher adiposity are hallmarks of pregnancy with maternal obesity and poor glucose tolerance, two conditions associated with decreased maternal insulin sensitivity. In non-pregnant individuals, adipokines, vasoactive peptides, and components of the immune system crosstalk with metabolic factors to generate signals triggering obesity and impaired insulin action. We have investigated circulating maternal and fetal cytokines and growth-factors as potential biochemical markers of fetal adiposity. Mothers and neonates were classified into three tertiles (T1-T3) using total neonatal fat mass as the outcome with 309 ± 25 g in T1, 478 ± 40 g in T2, and 529 ± 39 g in T3. Umbilical cord endothelin-1 (ET-1), C-peptide, and leptin were higher in T3 and T2 versus T1. Only cord leptin was strongly associated with fetal fat mass (P
AB - Fetal overgrowth and higher adiposity are hallmarks of pregnancy with maternal obesity and poor glucose tolerance, two conditions associated with decreased maternal insulin sensitivity. In non-pregnant individuals, adipokines, vasoactive peptides, and components of the immune system crosstalk with metabolic factors to generate signals triggering obesity and impaired insulin action. We have investigated circulating maternal and fetal cytokines and growth-factors as potential biochemical markers of fetal adiposity. Mothers and neonates were classified into three tertiles (T1-T3) using total neonatal fat mass as the outcome with 309 ± 25 g in T1, 478 ± 40 g in T2, and 529 ± 39 g in T3. Umbilical cord endothelin-1 (ET-1), C-peptide, and leptin were higher in T3 and T2 versus T1. Only cord leptin was strongly associated with fetal fat mass (P
KW - Cytokines
KW - Fetal adiposity
KW - Growth factors
KW - Obesity
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=29344456405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29344456405&partnerID=8YFLogxK
U2 - 10.1016/j.jsgi.2005.10.003
DO - 10.1016/j.jsgi.2005.10.003
M3 - Article
C2 - 16378913
AN - SCOPUS:29344456405
VL - 13
SP - 53
EP - 57
JO - Journal of the Society for Gynecologic Investigation
JF - Journal of the Society for Gynecologic Investigation
SN - 1071-5576
IS - 1
ER -