Maternal plasma soluble TRAIL is decreased in preeclampsia

Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Roberto Romero, Steven J. Korzeniewski, Tamara Stampalija, Nandor Gabor Than, Zhong Dong, Jezid Miranda, Lami Yeo, Sonia S. Hassan

Research output: Contribution to journalArticlepeer-review


Objective: Preeclampsia (PE) is characterized by systemic intravascular inflammation. Women who develop PE are at an increased risk for cardiovascular disease in later life. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) has anti-atherosclerotic effects in endothelial cells and can mediate neutrophil apoptosis. Low soluble TRAIL (sTRAIL) and high C-reactive protein (CRP) concentrations are associated with an increased risk of future cardiovascular disease in non-pregnant individuals. The aim of this study was to determine whether maternal plasma concentrations of sTRAIL and CRP differ between women with PE and those with uncomplicated pregnancies. Method: This cross-sectional study included women with an uncomplicated pregnancy (n=93) and those with PE (n=52). Maternal plasma concentrations of sTRAIL and CRP concentrations were determined by ELISA. Results: 1) The median plasma sTRAIL concentration (pg/mL) was significantly lower and the median plasma CRP concentration was significantly higher in women with PE than in those with an uncomplicated pregnancy (25.55 versus 29.17; p=0.03 and 8.0 versus 4.1; p=0.001, respectively); 2) the median plasma concentration sTRAIL/CRP ratio was two-fold lower in women with PE than in those with an uncomplicated pregnancy (p

Original languageEnglish
Pages (from-to)217-227
Number of pages11
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number3
Publication statusPublished - Feb 2014


  • Apoptosis
  • C-reactive protein
  • Coronary artery disease
  • Endothelial cell
  • Intravascular inflammation
  • Neutrophil apoptosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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