Maternal predictors of HIV vertical transmission

Antonella d Arminio Monforte, Marina Ravizza, Maria Luisa Muggiasca, Roberto Novati, Massimo Musicco, Gian Vittorio Zuccotti, Guido Cavalli, Nicola Principi, Mario Conti, Giorgio Pardi, Adriano Lazzarin

Research output: Contribution to journalArticlepeer-review

Abstract

We performed a retrospective study of 57 HIV-positive pregnant women and their children to look for maternal parameters related to rates of vertical transmission of HIV. Sixteen (28%) infants were HIV-infected. There was no positive correlation between maternal risk factors for HIV and vertical transmission of HIV. Multiparity seemed to be related to a higher prevalence of vertical transmission, whereas neither preterm delivery nor cesarean section resulted in different rates of vertical transmission, although they tended to have some protective effect. Maternal β2-microglobulin and serum neopterin levels were not related to different rates of vertical transmission of HIV. CD4+ cell counts did so only when cut-off values of 400/mm3 were taken. All the women in CDC group IV and all the HIV p24 antigen-positive transmitted the infection to their infants, whereas only 7 48 women in CDC groups II and III (P = 0.000006) and 9 48 HIV p24 antigen negative women (P = 0.00006) gave birth to infected infants. No other maternal characteristics were associated with different rates of vertical transmission in a multivariate analysis restricted to women in CDC groups II and III and with HIV p24 antigen negativity.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume42
Issue number2
DOIs
Publication statusPublished - Nov 26 1991

Keywords

  • HIV p24 Ag
  • Symptomatic HIV infection
  • Vertical transmission

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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