Maternal thrombophilia and adverse pregnancy outcome: A case-control study

Maria Gabriella Mazzucconi, Vitaliana De Sanctis, Marco Alfò, Maria Antonietta Amendolea, Laura Conti, Cristina Santoro, Erminia Baldacci, Monica Peraino, Cesare Masala

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. Patients and Methods: A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors. Results: Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p <0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls. Conclusion: Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalActa Haematologica
Volume133
Issue number2
DOIs
Publication statusPublished - Feb 17 2015

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Thrombophilia
Pregnancy Outcome
Case-Control Studies
Mothers
Pregnancy
Reproductive History
Spontaneous Abortion
Control Groups

Keywords

  • Miscarriage
  • Pregnancy
  • Thrombophilia

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Mazzucconi, M. G., De Sanctis, V., Alfò, M., Amendolea, M. A., Conti, L., Santoro, C., ... Masala, C. (2015). Maternal thrombophilia and adverse pregnancy outcome: A case-control study. Acta Haematologica, 133(2), 242-248. https://doi.org/10.1159/000363048

Maternal thrombophilia and adverse pregnancy outcome : A case-control study. / Mazzucconi, Maria Gabriella; De Sanctis, Vitaliana; Alfò, Marco; Amendolea, Maria Antonietta; Conti, Laura; Santoro, Cristina; Baldacci, Erminia; Peraino, Monica; Masala, Cesare.

In: Acta Haematologica, Vol. 133, No. 2, 17.02.2015, p. 242-248.

Research output: Contribution to journalArticle

Mazzucconi, MG, De Sanctis, V, Alfò, M, Amendolea, MA, Conti, L, Santoro, C, Baldacci, E, Peraino, M & Masala, C 2015, 'Maternal thrombophilia and adverse pregnancy outcome: A case-control study', Acta Haematologica, vol. 133, no. 2, pp. 242-248. https://doi.org/10.1159/000363048
Mazzucconi MG, De Sanctis V, Alfò M, Amendolea MA, Conti L, Santoro C et al. Maternal thrombophilia and adverse pregnancy outcome: A case-control study. Acta Haematologica. 2015 Feb 17;133(2):242-248. https://doi.org/10.1159/000363048
Mazzucconi, Maria Gabriella ; De Sanctis, Vitaliana ; Alfò, Marco ; Amendolea, Maria Antonietta ; Conti, Laura ; Santoro, Cristina ; Baldacci, Erminia ; Peraino, Monica ; Masala, Cesare. / Maternal thrombophilia and adverse pregnancy outcome : A case-control study. In: Acta Haematologica. 2015 ; Vol. 133, No. 2. pp. 242-248.
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