Maternal thrombophilia and the risk of recurrence of preeclampsia

Fabio Facchinetti, Luca Marozio, Tiziana Frusca, Elvira Grandone, Paolo Venturini, Giovanni Luca Tiscia, Sonia Zatti, Chiara Benedetto

Research output: Contribution to journalArticlepeer-review


Objective: The aim of this prospective study was to determine the impact of thrombophilia on the recurrence of preeclampsia. Study Design: In a multicenter, observational, cohort design, 172 white patients with a previous pregnancy complicated by preeclampsia were observed in the next pregnancy. They were evaluated for heritable thrombophilia (factor V Leiden and factor II G20210A mutations, protein S, protein C, and antithrombin deficiency), hyperhomocystinemia, lupus anticoagulant, and anticardiolipin antibodies. Development of preeclampsia and maternal complications and both gestational age at delivery and birthweight were recorded. Results: Sixty women (34.9%) showed the presence of a thrombophilic defect. They had a higher risk for the recurrence of preeclampsia (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.2-5.1), compared to patients without thrombophilia. Similar findings were observed considering only heritable thrombophilia. Thrombophilic patients were at increased risk for the occurrence of very early preterm delivery (<32 weeks; OR, 11.6; 95% CI, 3.4-43.2). Conclusion: When counseling white women with a history of preeclampsia, screening for thrombophilia can be useful for preconceptional counseling and pregnancy management.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
Publication statusPublished - Jan 2009


  • factor V Leiden
  • heritable thrombophilia
  • preeclampsia
  • prothrombin mutation
  • thrombophilia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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