### Abstract

This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.

Original language | English |
---|---|

Pages (from-to) | 154-164 |

Number of pages | 11 |

Journal | Haematologica |

Volume | 79 |

Issue number | 2 |

Publication status | Published - 1994 |

### Fingerprint

### Keywords

- cost-effectiveness
- erythropoietin therapy
- mathematical modeling
- uremic anemia

### ASJC Scopus subject areas

- Hematology

### Cite this

*Haematologica*,

*79*(2), 154-164.

**Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?** / Bellazzi, R.; Siviero, C.; Bellazzi, R.

Research output: Contribution to journal › Article

*Haematologica*, vol. 79, no. 2, pp. 154-164.

}

TY - JOUR

T1 - Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?

AU - Bellazzi, R.

AU - Siviero, C.

AU - Bellazzi, R.

PY - 1994

Y1 - 1994

N2 - This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.

AB - This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.

KW - cost-effectiveness

KW - erythropoietin therapy

KW - mathematical modeling

KW - uremic anemia

UR - http://www.scopus.com/inward/record.url?scp=0028232996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028232996&partnerID=8YFLogxK

M3 - Article

C2 - 8063263

AN - SCOPUS:0028232996

VL - 79

SP - 154

EP - 164

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 2

ER -