### Abstract

This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.

Original language | English |
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Pages (from-to) | 154-164 |

Number of pages | 11 |

Journal | Haematologica |

Volume | 79 |

Issue number | 2 |

Publication status | Published - 1994 |

### Keywords

- cost-effectiveness
- erythropoietin therapy
- mathematical modeling
- uremic anemia

### ASJC Scopus subject areas

- Hematology

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## Cite this

Bellazzi, R., Siviero, C., & Bellazzi, R. (1994). Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?

*Haematologica*,*79*(2), 154-164.