Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?

R. Bellazzi, C. Siviero, R. Bellazzi

Research output: Contribution to journalArticle

Abstract

This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.

Original languageEnglish
Pages (from-to)154-164
Number of pages11
JournalHaematologica
Volume79
Issue number2
Publication statusPublished - 1994

Keywords

  • cost-effectiveness
  • erythropoietin therapy
  • mathematical modeling
  • uremic anemia

ASJC Scopus subject areas

  • Hematology

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