Mating between two balanced translocation carriers in two unrelated families

B. Dallapiccola, L. Chessa, V. Brinchi, M. Frontali, E. Gandini

Research output: Contribution to journalArticle

Abstract

Partial trisomy 9p and a 13/14 translocation occurred in the daughter of a t(5;9)(p15;p12) mother and a t(13;14) (p11;q11) father. Two additional offspring displayed a normal karyotype and a translocation trisomy 13 respectively. Two first cousins, selected for chromosome analysis because of a spontaneous abortion, were found to have an identical translocation t(14;21)(p11;q11). Their second pregnancy was monitored by midtrimester amniocentesis and disclosed a balanced fetus. The different zygotic chromosome constitutions and the counselling problems in the marriages between two balanced translocation carriers are discussed.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalHuman Genetics
Volume65
Issue number2
DOIs
Publication statusPublished - Dec 1983

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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