Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension

Giuseppe Derosa, Angela D'Angelo, Leonardina Ciccarelli, Mario N. Piccinni, Fabio Pricolo, Sibilla Salvadeo, Lorenza Montagna, Alessia Gravina, Ilaria Ferrari, Simona Galli, Sonia Paniga, Carmine Tinelli, Arrigo F G Cicero

Research output: Contribution to journalArticle

Abstract

There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p <.0001). Significant increase was also observed for MMP-9 level and activity (p <.0001) and for TIPM-1 (p <.0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalEndothelium: Journal of Endothelial Cell Research
Volume13
Issue number3
DOIs
Publication statusPublished - May 2006

Keywords

  • Extracellular matrix
  • Hypertension
  • Metalloproteinases
  • Tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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    Derosa, G., D'Angelo, A., Ciccarelli, L., Piccinni, M. N., Pricolo, F., Salvadeo, S., Montagna, L., Gravina, A., Ferrari, I., Galli, S., Paniga, S., Tinelli, C., & Cicero, A. F. G. (2006). Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. Endothelium: Journal of Endothelial Cell Research, 13(3), 227-231. https://doi.org/10.1080/10623320600780942