Metalloproteinasi di matrice e tratto gastrointestinale

Translated title of the contribution: Matrix metalloproteinases and the gastrointestinal tract

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are a family of enzymes whose main function is degradation of the extracellular matrix. These enzymes are present in healthy human gastrointestinal mucosa, where they contribute to the maintenance of epithelial turnover, barrier integrity and mucosal functions, however, our principal interest relates to their role in certain disease states in which breakdown of the extracellular matrix is a key feature. It is current opinion that activated T lymphocytes are responsible of the damage of the gut mucosa, and now it is clear that their action is mediated by an increased production of MMPs by stromal cells, glandular epithelial cells, macrophages and neoplastic cells. In gastrointestinal tract, the pathological conditions in which a pivotal role of MMPs has been demonstrated include: peptic ulcer, coeliac disease, inflammatory bowel disease and cancer. Natural inhibitors of MMPs exist, and synthetic inhibitors have been developed which offer the hope for new treatment options in these pathological conditions.

Original languageItalian
Pages (from-to)9-13
Number of pages5
JournalEOS Rivista di Immunologia ed Immunofarmacologia
Volume21
Issue number1
Publication statusPublished - 2001

Fingerprint

Matrix Metalloproteinases
Gastrointestinal Tract
Extracellular Matrix
Mucous Membrane
Celiac Disease
Enzymes
Stromal Cells
Peptic Ulcer
Inflammatory Bowel Diseases
Epithelial Cells
Macrophages
Maintenance
T-Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

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abstract = "Matrix metalloproteinases (MMPs) are a family of enzymes whose main function is degradation of the extracellular matrix. These enzymes are present in healthy human gastrointestinal mucosa, where they contribute to the maintenance of epithelial turnover, barrier integrity and mucosal functions, however, our principal interest relates to their role in certain disease states in which breakdown of the extracellular matrix is a key feature. It is current opinion that activated T lymphocytes are responsible of the damage of the gut mucosa, and now it is clear that their action is mediated by an increased production of MMPs by stromal cells, glandular epithelial cells, macrophages and neoplastic cells. In gastrointestinal tract, the pathological conditions in which a pivotal role of MMPs has been demonstrated include: peptic ulcer, coeliac disease, inflammatory bowel disease and cancer. Natural inhibitors of MMPs exist, and synthetic inhibitors have been developed which offer the hope for new treatment options in these pathological conditions.",
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