Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life

Giuseppe Riezzo, Flavia Indrio, Francesco Raimondi, Osvaldo Montagna, Gennaro Salvia, Bisceglia Massimo, Lorenzo Polimeno, Luciano Cavallo, Ruggiero Francavilla

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Immaturity of motility, intestinal epithelial barrier function and absorptive capacity may play a role in the pathophysiology of intestinal diseases in preterms. We determined the gastric electrical activity and emptying, and intestinal permeability, in preterm newborns to verify if a maturation pattern exists in preterm newborns during the first month of life. Patients and methods: Eighteen preterm newborns (median 34 wks, range 2 wks) completed the study. They underwent the recording of gastric electrical activity by means of cutaneous electrogastrography, the ultrasound examination of gastric emptying, and the lactulose-to-mannitol ratio from permeability- absorption test on days 3, 7, 15, and 30 after birth. Results: Gastric electrical activity and emptying showed only slight changes between day 3 and day 7. On the contrary, an evident maturation in permeability, expressed as L/Mratio, was evident over time (Friedman Repeated Measures Analysis, p = 0.004). Conclusion: In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life.

Original languageEnglish
Article number6
JournalItalian Journal of Pediatrics
Volume35
Issue number6
DOIs
Publication statusPublished - Mar 15 2009

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Gastric Emptying
Permeability
Stomach
Newborn Infant
Parturition
Lactulose
Intestinal Diseases
Gastrointestinal Motility
Mannitol
Gestational Age
Motor Activity
Skin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life. / Riezzo, Giuseppe; Indrio, Flavia; Raimondi, Francesco; Montagna, Osvaldo; Salvia, Gennaro; Massimo, Bisceglia; Polimeno, Lorenzo; Cavallo, Luciano; Francavilla, Ruggiero.

In: Italian Journal of Pediatrics, Vol. 35, No. 6, 6, 15.03.2009.

Research output: Contribution to journalArticle

Riezzo, Giuseppe ; Indrio, Flavia ; Raimondi, Francesco ; Montagna, Osvaldo ; Salvia, Gennaro ; Massimo, Bisceglia ; Polimeno, Lorenzo ; Cavallo, Luciano ; Francavilla, Ruggiero. / Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life. In: Italian Journal of Pediatrics. 2009 ; Vol. 35, No. 6.
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AU - Salvia, Gennaro

AU - Massimo, Bisceglia

AU - Polimeno, Lorenzo

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