Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis

Paola Bossu, Gary G. Singer, Pietro Andres, Rachel Ettinger, Ann Marshak-Rothstein, Abul K. Abbas

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Abstract

The goal of this study was to examine the functional responses and tolerance susceptibility of T lymphocytes from mice of the autoimmune strain, MRL/lpr. A population of autoreactive CD4+ T cells can be readily expanded from the lymphoid tissues of young lpr mice. Lines of IL-2-producing autoreactive and alloreactive lpr and alloreactive +/+ T cells were developed to study their responses to tolerance-inducing stimuli. Culture of +/+ T cells with high concentrations of immobilized anti-CD3 antibody induces both functional anergy and apoptosis. By contrast, lpr-derived T cell lines are relatively resistant to anergy and apoptosis. The implications of these findings for the development of autoimmunity, and the possible role of the Fas Ag in determining resistance or susceptibility to tolerance, are discussed.

Original languageEnglish
Pages (from-to)7233-7239
Number of pages7
JournalJournal of Immunology
Volume151
Issue number12
Publication statusPublished - Dec 15 1993

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ASJC Scopus subject areas

  • Immunology

Cite this

Bossu, P., Singer, G. G., Andres, P., Ettinger, R., Marshak-Rothstein, A., & Abbas, A. K. (1993). Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. Journal of Immunology, 151(12), 7233-7239.