May T1 diabetes mellitus protect from asthma?

Maria Angela Tosca, Michela Silòvestri, Giuseppe D'Annunzio, Renata Lorini, Giovanni Arturo Rossi, Giorgio Ciprandi

Research output: Contribution to journalArticlepeer-review


Background: Type 1 diabetes mellitus (T1DM) may be associated with allergy. It was previously reported that >20% of children with T1DM had allergic rhinitis (AR), but none was asthmatic. This finding was surprising as allergic rhinitis is frequently associated with asthma and asthma prevalence is about 10% of the general paediatric population. Thus, it was hypothesized that T1DM could protect from asthma. Objectives: The aim of this preliminary study was to evaluate the pulmonary function and the response to bronchodilation testing in children, suffering from T1DM with associated AR, comparing them with a control group of children with AR alone. Methods: Twenty children with T1DM and AR were compared with 59 children with AR alone; spirometry and bronchodilation testing were performed in all patients. Results: There were no statistically significant differences in both "at baseline" and after bronchodilation testing about FVC, FEV1, and FEF25-75 values. However, changes in "post-bronchodilator" values of FEF25-75 (δFEF25-75) were significantly higher in children with AR alone than in children with T1DM and AR (p=0.04). Conclusions: This preliminary study could sustain the hypothesis that T1DM in children suffering also from AR might exert a protective effect of preventing the possible evolution in asthma.

Original languageEnglish
Pages (from-to)288-291
Number of pages4
JournalAllergologia et Immunopathologia
Issue number5
Publication statusPublished - Sep 2013


  • Allergic rhinitis
  • Asthma
  • Bronchodilation
  • Diabetes
  • FEF25-75%

ASJC Scopus subject areas

  • Immunology and Allergy


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