MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus-related cervical cancer

Ludovica Segat, Sergio Crovella, Manola Comar, Michele Milanese, Nunzia Zanotta, Annalisa Fabris, Chiara Trevisiol, Tatiana Rossi, Francesco De Seta, Cesare Campello

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated whether there is a correlation between MBL2 polymorphisms and the host susceptibility to human papillomavirus (HPV) infection and cancer development. Toward this end, we analyzed MBL2 exon 1 polymorphisms in 172 women infected by strains of HPV that are associated with high-risk of cervical cancer development (or "high-risk" HPV infection), 105 of whom had HPV-related squamous cell carcinoma of the cervix (SCC), as well as 105 women not infected by HPV. We demonstrated an association of MBL2 polymorphisms with high-risk HPV infection in women without SCC who showed increased presence of the mutant MBL2 0 allele and 0/0 genotype as compared with women with SCC and healthy controls. No correlation with MBL2 polymorphisms was found in women who developed cancer. Therefore we propose that MBL2 polymorphisms responsible for defective production of mannose binding lectin (MBL) protein play a role in the increased susceptibility to high-risk HPV infection but not to cervical cancer onset and development.

Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalHuman Immunology
Volume70
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Cervical cancer
  • Genetic polymorphisms
  • High-risk HPV
  • Innate immunity
  • MBL2

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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