MBL2 genetic polymorphisms in Italian children with adenotonsillar hypertrophy

Domenico Leonardo Grasso, Veronica Ileana Guerci, Elisabetta Zocconi, Michele Milanese, Ludovica Segat, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

We investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to recurrent tonsillitis in a selected group of Italian children and healthy controls. Significant difference has been observed in MBL2 genotype and allelic frequencies between children with recurrent tonsillitis and healthy controls matched for sex and age. Children characterized by a "low MBL" producer genotype, namely 00, are more prone to recurrent tonsillitis when compared to the healthy controls. To our knowledge this is the first report on the role of MBL2 polymorphisms in adenotonsillar hypertrophy and our results shown that presence of MBL2 00 genotype could be used as a prognostic marker in subjects with adenotonsillar hypertrophy.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Innate immune system
  • MBL
  • Tonsillitis

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

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