TY - JOUR
T1 - McKittrick-Wheelock syndrome
T2 - A rare cause of acute renal failure and hypokalemia not to be overlooked
AU - Podestà, Manuel Alfredo
AU - Cucchiari, David
AU - Merizzoli, Elisa
AU - Elmore, Ugo
AU - Angelini, Claudio
AU - Badalamenti, Salvatore
PY - 2014
Y1 - 2014
N2 - McKittrick-Wheelock syndrome is a rare disorder in which a colorectal tumor (usually a villous adenoma) determines secretory mucous diarrhea, which in turn leads to prerenal acute renal failure, hyponatremia, hypokalemia and metabolic acidosis. Even though the outcome is usually favorable with complete recovery after surgery, the diagnosis is often delayed, making the patient susceptible to life-threatening complications, mainly severe acidosis and hypokalemia. We present two paradigmatic cases with extreme electrolytes imbalance and complete recovery following the appropriate treatment. The pathogenesis of this degenerative condition is discussed in detail.
AB - McKittrick-Wheelock syndrome is a rare disorder in which a colorectal tumor (usually a villous adenoma) determines secretory mucous diarrhea, which in turn leads to prerenal acute renal failure, hyponatremia, hypokalemia and metabolic acidosis. Even though the outcome is usually favorable with complete recovery after surgery, the diagnosis is often delayed, making the patient susceptible to life-threatening complications, mainly severe acidosis and hypokalemia. We present two paradigmatic cases with extreme electrolytes imbalance and complete recovery following the appropriate treatment. The pathogenesis of this degenerative condition is discussed in detail.
KW - Acute renal failure
KW - Hypokalemia
KW - Hyponatremia
KW - Metabolic acidosis
KW - Villous adenoma
UR - http://www.scopus.com/inward/record.url?scp=84901934057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901934057&partnerID=8YFLogxK
U2 - 10.3109/0886022X.2014.890056
DO - 10.3109/0886022X.2014.890056
M3 - Article
C2 - 24564376
AN - SCOPUS:84901934057
VL - 36
SP - 811
EP - 813
JO - Journal of Dialysis
JF - Journal of Dialysis
SN - 0886-022X
IS - 5
ER -