McKittrick-Wheelock syndrome: A rare cause of acute renal failure and hypokalemia not to be overlooked

Manuel Alfredo Podestà, David Cucchiari, Elisa Merizzoli, Ugo Elmore, Claudio Angelini, Salvatore Badalamenti

Research output: Contribution to journalArticlepeer-review


McKittrick-Wheelock syndrome is a rare disorder in which a colorectal tumor (usually a villous adenoma) determines secretory mucous diarrhea, which in turn leads to prerenal acute renal failure, hyponatremia, hypokalemia and metabolic acidosis. Even though the outcome is usually favorable with complete recovery after surgery, the diagnosis is often delayed, making the patient susceptible to life-threatening complications, mainly severe acidosis and hypokalemia. We present two paradigmatic cases with extreme electrolytes imbalance and complete recovery following the appropriate treatment. The pathogenesis of this degenerative condition is discussed in detail.

Original languageEnglish
Pages (from-to)811-813
Number of pages3
JournalRenal Failure
Issue number5
Publication statusPublished - 2014


  • Acute renal failure
  • Hypokalemia
  • Hyponatremia
  • Metabolic acidosis
  • Villous adenoma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Medicine(all)


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