MCP-1 A-2518G polymorphism: Effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels

Daniela Galimberti, Eliana Venturelli, Chiara Villa, Chiara Fenoglio, Francesca Clerici, Alessandra Marcone, Luisa Benussi, Francesca Cortini, Diego Scalabrini, Luca Perini, Ilaria Restelli, Giuliano Binetti, Stefano Cappa, Claudio Mariani, Nereo Bresolin, Elio Scarpini

Research output: Contribution to journalArticle

Abstract

The distribution of the MCP-1 A-2518G single nucleotide polymorphisms (SNP) was analyzed in a population of 212 patients with frontotemporal lobar degeneration (FTLD) compared with 203 age-matched controls. A significantly decreased allelic frequency of the G allele in patients compared with controls was observed (21.1 versus 29.3%, P = 0.011, OR: 0.59, CI: 0.40-0.87). Stratifying according to gender, the association was maintained in male patients versus male controls (17.8 versus 29.4%, P = 0.016, OR = 0.46, 95% CI: 0.25-0.84), but not in female patients compared with female controls (23.5 versus 29.2%, P > 0.05). The frequency of apolipoprotein E ε4 carriers was increased in patients (26.4 versus 13.8%, P = 0.0015, OR: 2.24, 95% CI: 1.37-3.67). Apolipoprotein E status did not influence the distribution of the A-2518G SNP. Monocyte chemotactic protein (MCP)-1 levels were determined in cerebrospinal fluid (CSF) collected from 23 patients and 17 controls. MCP-1 CSF levels were increased in patients compared with controls (449.01 ± 27.57 versus 364.19 ± 23.75 pg/ml, P = 0.011). Stratifying patients according to the presence of the polymorphic allele, significantly increased CSF MCP-1 levels were observed in carriers of the G allele compared with non-carriers (502.21 ± 44.57 versus 395.87 ± 21.92 pg/ml, P = 0.045). The MCP-1 A-2518G SNP acts as protective factor for sporadic FTLD, possibly by influencing MCP-1 production.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalJournal of Alzheimer's Disease
Volume17
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Cerebrospinal fluid
  • Monocyte chemotactic protein-1
  • Risk factor
  • Single nucleotide polymorphism
  • Sporadic frontotemporal lobar degeneration

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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