TY - JOUR
T1 - mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512
AU - Di Pilato, Vincenzo
AU - Arena, Fabio
AU - Tascini, Carlo
AU - Cannatelli, Antonio
AU - Henrici De Angelis, Lucia
AU - Fortunato, Simona
AU - Giani, Tommaso
AU - Menichetti, Francesco
AU - Rossolini, Gian Maria
PY - 2016/9/1
Y1 - 2016/9/1
N2 - A novel mcr variant, named mcr-1.2, encoding a Gln3-to-Leu functional variant of MCR-1, was detected in a KPC-3-producing ST512 Klebsiella pneumoniae isolate collected in Italy from a surveillance rectal swab from a leukemic child. The mcr-1.2 gene was carried on a transferable IncX4 plasmid whose structure was very similar to that of mcr-1-bearing plasmids previously found in Escherichia coli and K. pneumoniae strains from geographically distant sites (Estonia, China, and South Africa).
AB - A novel mcr variant, named mcr-1.2, encoding a Gln3-to-Leu functional variant of MCR-1, was detected in a KPC-3-producing ST512 Klebsiella pneumoniae isolate collected in Italy from a surveillance rectal swab from a leukemic child. The mcr-1.2 gene was carried on a transferable IncX4 plasmid whose structure was very similar to that of mcr-1-bearing plasmids previously found in Escherichia coli and K. pneumoniae strains from geographically distant sites (Estonia, China, and South Africa).
UR - http://www.scopus.com/inward/record.url?scp=84983489125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983489125&partnerID=8YFLogxK
U2 - 10.1128/AAC.01075-16
DO - 10.1128/AAC.01075-16
M3 - Article
AN - SCOPUS:84983489125
VL - 60
SP - 5612
EP - 5615
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -