mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512

Vincenzo Di Pilato, Fabio Arena, Carlo Tascini, Antonio Cannatelli, Lucia Henrici De Angelis, Simona Fortunato, Tommaso Giani, Francesco Menichetti, Gian Maria Rossolini

Research output: Contribution to journalArticle

Abstract

A novel mcr variant, named mcr-1.2, encoding a Gln3-to-Leu functional variant of MCR-1, was detected in a KPC-3-producing ST512 Klebsiella pneumoniae isolate collected in Italy from a surveillance rectal swab from a leukemic child. The mcr-1.2 gene was carried on a transferable IncX4 plasmid whose structure was very similar to that of mcr-1-bearing plasmids previously found in Escherichia coli and K. pneumoniae strains from geographically distant sites (Estonia, China, and South Africa).

Original languageEnglish
Pages (from-to)5612-5615
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Di Pilato, V., Arena, F., Tascini, C., Cannatelli, A., Henrici De Angelis, L., Fortunato, S., Giani, T., Menichetti, F., & Rossolini, G. M. (2016). mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512. Antimicrobial Agents and Chemotherapy, 60(9), 5612-5615. https://doi.org/10.1128/AAC.01075-16