MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients

Maria Lina Tornesello; Luigi Buonaguro; Medea Cristillo; Bennon Biryahwaho; Robert Downing; Angelo Hatzakis; Elvio Alessi; Marco Cusini; Vincenzo Ruocco; Enza Viviano; Nino Romano; Edward Katongole-Mbidde; Franco M. Buonaguro

doi:10.3109/1354750X.2010.525664

MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients

Maria Lina Tornesello, Luigi Buonaguro, Medea Cristillo, Bennon Biryahwaho, Robert Downing, Angelo Hatzakis, Elvio Alessi, Marco Cusini, Vincenzo Ruocco, Enza Viviano, Nino Romano, Edward Katongole-Mbidde, Franco M. Buonaguro

Research output: Contribution to journal › Article › peer-review

Abstract

A single-nucleotide polymorphism in the MDM2 promoter (SNP309; rs2279744) causes elevated transcription of this major negative regulator of p53 in several cancer types. We investigated MDM2 SNP309 and CDKN1A (p21/Waf1/Cip1) codon 31 (rs1801270) polymorphisms in 86 cases of cutaneous Kaposi's sarcoma (KS) from African and Caucasian patients, and 210 healthy controls. A significant increase of the MDM2 SNP309 T/G genotype was observed among classic KS cases (odds ratio 2.38, 95% confidence interval 1.0-5.5). Frequencies of CDKN1A codon 31 genotypes were not significantly different between cases and controls. The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients.

Original language	English
Pages (from-to)	42-50
Number of pages	9
Journal	Biomarkers
Volume	16
Issue number	1
DOIs	https://doi.org/10.3109/1354750X.2010.525664
Publication status	Published - Feb 2011

Keywords

CDKN1A
Genetic polymorphisms
Kaposi's sarcoma.
MDM2

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2010.525664

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Tornesello, M. L., Buonaguro, L., Cristillo, M., Biryahwaho, B., Downing, R., Hatzakis, A., Alessi, E., Cusini, M., Ruocco, V., Viviano, E., Romano, N., Katongole-Mbidde, E., & Buonaguro, F. M. (2011). MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients. Biomarkers, 16(1), 42-50. https://doi.org/10.3109/1354750X.2010.525664

MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients. / Tornesello, Maria Lina ; Buonaguro, Luigi; Cristillo, Medea; Biryahwaho, Bennon; Downing, Robert; Hatzakis, Angelo; Alessi, Elvio; Cusini, Marco; Ruocco, Vincenzo; Viviano, Enza; Romano, Nino; Katongole-Mbidde, Edward; Buonaguro, Franco M.

In: Biomarkers, Vol. 16, No. 1, 02.2011, p. 42-50.

Research output: Contribution to journal › Article › peer-review

Tornesello, Maria Lina ; Buonaguro, Luigi ; Cristillo, Medea ; Biryahwaho, Bennon ; Downing, Robert ; Hatzakis, Angelo ; Alessi, Elvio ; Cusini, Marco ; Ruocco, Vincenzo ; Viviano, Enza ; Romano, Nino ; Katongole-Mbidde, Edward ; Buonaguro, Franco M. / MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients. In: Biomarkers. 2011 ; Vol. 16, No. 1. pp. 42-50.

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AB - A single-nucleotide polymorphism in the MDM2 promoter (SNP309; rs2279744) causes elevated transcription of this major negative regulator of p53 in several cancer types. We investigated MDM2 SNP309 and CDKN1A (p21/Waf1/Cip1) codon 31 (rs1801270) polymorphisms in 86 cases of cutaneous Kaposi's sarcoma (KS) from African and Caucasian patients, and 210 healthy controls. A significant increase of the MDM2 SNP309 T/G genotype was observed among classic KS cases (odds ratio 2.38, 95% confidence interval 1.0-5.5). Frequencies of CDKN1A codon 31 genotypes were not significantly different between cases and controls. The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients.

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MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients

Abstract

Keywords

ASJC Scopus subject areas

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