TY - JOUR
T1 - MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients
AU - Tornesello, Maria Lina
AU - Buonaguro, Luigi
AU - Cristillo, Medea
AU - Biryahwaho, Bennon
AU - Downing, Robert
AU - Hatzakis, Angelo
AU - Alessi, Elvio
AU - Cusini, Marco
AU - Ruocco, Vincenzo
AU - Viviano, Enza
AU - Romano, Nino
AU - Katongole-Mbidde, Edward
AU - Buonaguro, Franco M.
PY - 2011/2
Y1 - 2011/2
N2 - A single-nucleotide polymorphism in the MDM2 promoter (SNP309; rs2279744) causes elevated transcription of this major negative regulator of p53 in several cancer types. We investigated MDM2 SNP309 and CDKN1A (p21/Waf1/Cip1) codon 31 (rs1801270) polymorphisms in 86 cases of cutaneous Kaposi's sarcoma (KS) from African and Caucasian patients, and 210 healthy controls. A significant increase of the MDM2 SNP309 T/G genotype was observed among classic KS cases (odds ratio 2.38, 95% confidence interval 1.0-5.5). Frequencies of CDKN1A codon 31 genotypes were not significantly different between cases and controls. The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients.
AB - A single-nucleotide polymorphism in the MDM2 promoter (SNP309; rs2279744) causes elevated transcription of this major negative regulator of p53 in several cancer types. We investigated MDM2 SNP309 and CDKN1A (p21/Waf1/Cip1) codon 31 (rs1801270) polymorphisms in 86 cases of cutaneous Kaposi's sarcoma (KS) from African and Caucasian patients, and 210 healthy controls. A significant increase of the MDM2 SNP309 T/G genotype was observed among classic KS cases (odds ratio 2.38, 95% confidence interval 1.0-5.5). Frequencies of CDKN1A codon 31 genotypes were not significantly different between cases and controls. The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients.
KW - CDKN1A
KW - Genetic polymorphisms
KW - Kaposi's sarcoma.
KW - MDM2
UR - http://www.scopus.com/inward/record.url?scp=79251528612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79251528612&partnerID=8YFLogxK
U2 - 10.3109/1354750X.2010.525664
DO - 10.3109/1354750X.2010.525664
M3 - Article
C2 - 20979563
AN - SCOPUS:79251528612
VL - 16
SP - 42
EP - 50
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 1
ER -