MDM2 SNP309 accelerates colorectal tumour formation in women

Garetri L. Bond, Chiara Menin, Roberta Bertorelle, Pia Alhopuro, Lauri A. Aaltonen, Arnold J. Levine

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Recent studies have shown that the G-allele of MDM2 SNP309 (T/G) in the p53 tumour suppressor pathway can accelerate tumorigenesis and alter the risk of various cancers in women and not in men. In this report, data are presented from two independent groups of patients that suggest that the G-allele of SNP309 accelerates colorectal tumour formation only in women, and that lend further support to the model that primarily female-specific hormones, such as oestrogen, could either directly or indirectly allow for the G-allele of SNP309 to accelerate tumour formation in women.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalJournal of Medical Genetics
Volume43
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Colorectal Neoplasms
Alleles
Neoplasms
Estrogens
Carcinogenesis
Hormones

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

MDM2 SNP309 accelerates colorectal tumour formation in women. / Bond, Garetri L.; Menin, Chiara; Bertorelle, Roberta; Alhopuro, Pia; Aaltonen, Lauri A.; Levine, Arnold J.

In: Journal of Medical Genetics, Vol. 43, No. 12, 12.2006, p. 950-952.

Research output: Contribution to journalArticle

Bond, Garetri L. ; Menin, Chiara ; Bertorelle, Roberta ; Alhopuro, Pia ; Aaltonen, Lauri A. ; Levine, Arnold J. / MDM2 SNP309 accelerates colorectal tumour formation in women. In: Journal of Medical Genetics. 2006 ; Vol. 43, No. 12. pp. 950-952.
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