MDR/XDR-TB management of patients and contacts:: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

G.B. Migliori; S. Tiberi; A. Zumla; E. Petersen; J.M. Chakaya; C. Wejse; M. Muñoz Torrico; R. Duarte; J.W. Alffenaar; H.S. Schaaf; B.J. Marais; D.M. Cirillo; R. Alagna; A. Rendon; E. Pontali; A. Piubello; J. Figueroa; G. Ferlazzo; A. García-Basteiro; R. Centis; D. Visca; L. D'Ambrosio; G. Sotgiu; T.A. Arkub; O.W. Akkerman; A. Aleksa; E. Belilovski; E. Bernal; F.-X. Blanc; M. Boeree; S. Borisov; J. Bruchfeld; J. Cadiñanos Loidi; J.A. Caminero; A.C. Carvalho; J.J. Cebrian Gallardo; null Charalampos; E. Danila; L. Davies Forsman; J. Denholm; K. Dheda; R. Diel; S. Diktanas; C. Dobler; M. Enwerem; S. Esposito; N. Escobar Salinas; A. Filippov; B. Formenti; J.M. García García; D. Goletti; R. Gomez Rosso; G. Gualano; P. Isaakidis; A. Kaluzhenina; S. Koirala; L. Kuksa; H. Kunst; Y. Li; C. Magis-Escurra; V. Manfrin; S. Manga; K. Manika; V. Marchese; E. Martínez Robles; A. Maryandyshev; A. Matteelli; A. Mariani; J. Mazza-Stalder; F. Mello; L. Mendoza; A. Mesi; S. Miliauskas; H. Mustafa Hamdan; N. Ndjeka; M. Nieto Marcos; T.H.M. Ottenhoff; D.J. Palmero; F. Palmieri; A. Papavasileiou; M.C. Payen; A. Pontarelli; M. Pretti Dalcolmo; S. Quirós Fernandez; R. Romero; D. Rossato Silva; A.P. Santos; B. Seaworth; M. Sinitsyn; A. Skrahina; I. Solovic; A. Spanevello; M. Tadolini; C. Torres; Z. Udwadia; M. van den Boom; G.V. Volchenkov; A. Yedilbayev; R. Zaleskis; J.P. Zellweger; the members of the Global Tuberculosis Network

doi:10.1016/j.ijid.2020.01.042

MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

G.B. Migliori, S. Tiberi, A. Zumla, E. Petersen, J.M. Chakaya, C. Wejse, M. Muñoz Torrico, R. Duarte, J.W. Alffenaar, H.S. Schaaf, B.J. Marais, D.M. Cirillo, R. Alagna, A. Rendon, E. Pontali, A. Piubello, J. Figueroa, G. Ferlazzo, A. García-Basteiro, R. CentisD. Visca, L. D'Ambrosio, G. Sotgiu, T.A. Arkub, O.W. Akkerman, A. Aleksa, E. Belilovski, E. Bernal, F.-X. Blanc, M. Boeree, S. Borisov, J. Bruchfeld, J. Cadiñanos Loidi, J.A. Caminero, A.C. Carvalho, J.J. Cebrian Gallardo, Charalampos, E. Danila, L. Davies Forsman, J. Denholm, K. Dheda, R. Diel, S. Diktanas, C. Dobler, M. Enwerem, S. Esposito, N. Escobar Salinas, A. Filippov, B. Formenti, J.M. García García, D. Goletti, R. Gomez Rosso, G. Gualano, P. Isaakidis, A. Kaluzhenina, S. Koirala, L. Kuksa, H. Kunst, Y. Li, C. Magis-Escurra, V. Manfrin, S. Manga, K. Manika, V. Marchese, E. Martínez Robles, A. Maryandyshev, A. Matteelli, A. Mariani, J. Mazza-Stalder, F. Mello, L. Mendoza, A. Mesi, S. Miliauskas, H. Mustafa Hamdan, N. Ndjeka, M. Nieto Marcos, T.H.M. Ottenhoff, D.J. Palmero, F. Palmieri, A. Papavasileiou, M.C. Payen, A. Pontarelli, M. Pretti Dalcolmo, S. Quirós Fernandez, R. Romero, D. Rossato Silva, A.P. Santos, B. Seaworth, M. Sinitsyn, A. Skrahina, I. Solovic, A. Spanevello, M. Tadolini, C. Torres, Z. Udwadia, M. van den Boom, G.V. Volchenkov, A. Yedilbayev, R. Zaleskis, J.P. Zellweger, the members of the Global Tuberculosis Network

Research output: Contribution to journal › Article › peer-review

Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.

The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.

After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Original language	English
Pages (from-to)	S15-S25
Number of pages	16
Journal	International Journal of Infectious Diseases
Volume	92
DOIs	https://doi.org/10.1016/j.ijid.2020.01.042
Publication status	Published - 2020

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10.1016/j.ijid.2020.01.042

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079627781&doi=10.1016%2fj.ijid.2020.01.042&partnerID=40&md5=67891f31193391bbc98e7bc63ca152c2

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Migliori, G. B., Tiberi, S., Zumla, A., Petersen, E., Chakaya, J. M., Wejse, C., Muñoz Torrico, M., Duarte, R., Alffenaar, J. W., Schaaf, H. S., Marais, B. J., Cirillo, D. M., Alagna, R., Rendon, A., Pontali, E., Piubello, A., Figueroa, J., Ferlazzo, G., García-Basteiro, A., ... Network, T. M. O. T. G. T. (2020). MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. International Journal of Infectious Diseases, 92, S15-S25. https://doi.org/10.1016/j.ijid.2020.01.042

MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. / Migliori, G.B.; Tiberi, S.; Zumla, A.; Petersen, E.; Chakaya, J.M.; Wejse, C.; Muñoz Torrico, M.; Duarte, R.; Alffenaar, J.W.; Schaaf, H.S.; Marais, B.J.; Cirillo, D.M.; Alagna, R.; Rendon, A.; Pontali, E.; Piubello, A.; Figueroa, J.; Ferlazzo, G.; García-Basteiro, A.; Centis, R.; Visca, D.; D'Ambrosio, L.; Sotgiu, G.; Arkub, T.A.; Akkerman, O.W.; Aleksa, A.; Belilovski, E.; Bernal, E.; Blanc, F.-X.; Boeree, M.; Borisov, S.; Bruchfeld, J.; Cadiñanos Loidi, J.; Caminero, J.A.; Carvalho, A.C.; Cebrian Gallardo, J.J.; Charalampos; Danila, E.; Davies Forsman, L.; Denholm, J.; Dheda, K.; Diel, R.; Diktanas, S.; Dobler, C.; Enwerem, M.; Esposito, S.; Escobar Salinas, N.; Filippov, A.; Formenti, B.; García García, J.M.; Goletti, D.; Gomez Rosso, R.; Gualano, G.; Isaakidis, P.; Kaluzhenina, A.; Koirala, S.; Kuksa, L.; Kunst, H.; Li, Y.; Magis-Escurra, C.; Manfrin, V.; Manga, S.; Manika, K.; Marchese, V.; Martínez Robles, E.; Maryandyshev, A.; Matteelli, A.; Mariani, A.; Mazza-Stalder, J.; Mello, F.; Mendoza, L.; Mesi, A.; Miliauskas, S.; Mustafa Hamdan, H.; Ndjeka, N.; Nieto Marcos, M.; Ottenhoff, T.H.M.; Palmero, D.J.; Palmieri, F.; Papavasileiou, A.; Payen, M.C.; Pontarelli, A.; Pretti Dalcolmo, M.; Quirós Fernandez, S.; Romero, R.; Rossato Silva, D.; Santos, A.P.; Seaworth, B.; Sinitsyn, M.; Skrahina, A.; Solovic, I.; Spanevello, A.; Tadolini, M.; Torres, C.; Udwadia, Z.; van den Boom, M.; Volchenkov, G.V.; Yedilbayev, A.; Zaleskis, R.; Zellweger, J.P.; Network, the members of the Global Tuberculosis.

In: International Journal of Infectious Diseases, Vol. 92, 2020, p. S15-S25.

Research output: Contribution to journal › Article › peer-review

Migliori, GB, Tiberi, S, Zumla, A, Petersen, E, Chakaya, JM, Wejse, C, Muñoz Torrico, M, Duarte, R, Alffenaar, JW, Schaaf, HS, Marais, BJ, Cirillo, DM , Alagna, R, Rendon, A, Pontali, E, Piubello, A, Figueroa, J, Ferlazzo, G, García-Basteiro, A, Centis, R , Visca, D , D'Ambrosio, L, Sotgiu, G, Arkub, TA, Akkerman, OW, Aleksa, A, Belilovski, E, Bernal, E, Blanc, F-X, Boeree, M, Borisov, S, Bruchfeld, J, Cadiñanos Loidi, J, Caminero, JA, Carvalho, AC, Cebrian Gallardo, JJ, Charalampos, Danila, E, Davies Forsman, L, Denholm, J, Dheda, K, Diel, R, Diktanas, S, Dobler, C, Enwerem, M, Esposito, S, Escobar Salinas, N, Filippov, A, Formenti, B, García García, JM, Goletti, D, Gomez Rosso, R, Gualano, G, Isaakidis, P, Kaluzhenina, A, Koirala, S, Kuksa, L, Kunst, H, Li, Y, Magis-Escurra, C, Manfrin, V, Manga, S, Manika, K, Marchese, V, Martínez Robles, E, Maryandyshev, A, Matteelli, A, Mariani, A, Mazza-Stalder, J, Mello, F, Mendoza, L, Mesi, A, Miliauskas, S, Mustafa Hamdan, H, Ndjeka, N, Nieto Marcos, M, Ottenhoff, THM, Palmero, DJ, Palmieri, F, Papavasileiou, A, Payen, MC, Pontarelli, A, Pretti Dalcolmo, M, Quirós Fernandez, S, Romero, R, Rossato Silva, D, Santos, AP, Seaworth, B, Sinitsyn, M, Skrahina, A, Solovic, I, Spanevello, A, Tadolini, M, Torres, C, Udwadia, Z, van den Boom, M, Volchenkov, GV, Yedilbayev, A, Zaleskis, R, Zellweger, JP & Network, TMOTGT 2020, 'MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network', International Journal of Infectious Diseases, vol. 92, pp. S15-S25. https://doi.org/10.1016/j.ijid.2020.01.042

Migliori, G.B. ; Tiberi, S. ; Zumla, A. ; Petersen, E. ; Chakaya, J.M. ; Wejse, C. ; Muñoz Torrico, M. ; Duarte, R. ; Alffenaar, J.W. ; Schaaf, H.S. ; Marais, B.J. ; Cirillo, D.M. ; Alagna, R. ; Rendon, A. ; Pontali, E. ; Piubello, A. ; Figueroa, J. ; Ferlazzo, G. ; García-Basteiro, A. ; Centis, R. ; Visca, D. ; D'Ambrosio, L. ; Sotgiu, G. ; Arkub, T.A. ; Akkerman, O.W. ; Aleksa, A. ; Belilovski, E. ; Bernal, E. ; Blanc, F.-X. ; Boeree, M. ; Borisov, S. ; Bruchfeld, J. ; Cadiñanos Loidi, J. ; Caminero, J.A. ; Carvalho, A.C. ; Cebrian Gallardo, J.J. ; Charalampos ; Danila, E. ; Davies Forsman, L. ; Denholm, J. ; Dheda, K. ; Diel, R. ; Diktanas, S. ; Dobler, C. ; Enwerem, M. ; Esposito, S. ; Escobar Salinas, N. ; Filippov, A. ; Formenti, B. ; García García, J.M. ; Goletti, D. ; Gomez Rosso, R. ; Gualano, G. ; Isaakidis, P. ; Kaluzhenina, A. ; Koirala, S. ; Kuksa, L. ; Kunst, H. ; Li, Y. ; Magis-Escurra, C. ; Manfrin, V. ; Manga, S. ; Manika, K. ; Marchese, V. ; Martínez Robles, E. ; Maryandyshev, A. ; Matteelli, A. ; Mariani, A. ; Mazza-Stalder, J. ; Mello, F. ; Mendoza, L. ; Mesi, A. ; Miliauskas, S. ; Mustafa Hamdan, H. ; Ndjeka, N. ; Nieto Marcos, M. ; Ottenhoff, T.H.M. ; Palmero, D.J. ; Palmieri, F. ; Papavasileiou, A. ; Payen, M.C. ; Pontarelli, A. ; Pretti Dalcolmo, M. ; Quirós Fernandez, S. ; Romero, R. ; Rossato Silva, D. ; Santos, A.P. ; Seaworth, B. ; Sinitsyn, M. ; Skrahina, A. ; Solovic, I. ; Spanevello, A. ; Tadolini, M. ; Torres, C. ; Udwadia, Z. ; van den Boom, M. ; Volchenkov, G.V. ; Yedilbayev, A. ; Zaleskis, R. ; Zellweger, J.P. ; Network, the members of the Global Tuberculosis. / MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. In: International Journal of Infectious Diseases. 2020 ; Vol. 92. pp. S15-S25.

@article{af684f292e914984996b045ffdf9bf43,

title = "MDR/XDR-TB management of patients and contacts:: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network",

abstract = "The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.",

author = "G.B. Migliori and S. Tiberi and A. Zumla and E. Petersen and J.M. Chakaya and C. Wejse and {Mu{\~n}oz Torrico}, M. and R. Duarte and J.W. Alffenaar and H.S. Schaaf and B.J. Marais and D.M. Cirillo and R. Alagna and A. Rendon and E. Pontali and A. Piubello and J. Figueroa and G. Ferlazzo and A. Garc{\'i}a-Basteiro and R. Centis and D. Visca and L. D'Ambrosio and G. Sotgiu and T.A. Arkub and O.W. Akkerman and A. Aleksa and E. Belilovski and E. Bernal and F.-X. Blanc and M. Boeree and S. Borisov and J. Bruchfeld and {Cadi{\~n}anos Loidi}, J. and J.A. Caminero and A.C. Carvalho and {Cebrian Gallardo}, J.J. and Charalampos and E. Danila and {Davies Forsman}, L. and J. Denholm and K. Dheda and R. Diel and S. Diktanas and C. Dobler and M. Enwerem and S. Esposito and {Escobar Salinas}, N. and A. Filippov and B. Formenti and {Garc{\'i}a Garc{\'i}a}, J.M. and D. Goletti and {Gomez Rosso}, R. and G. Gualano and P. Isaakidis and A. Kaluzhenina and S. Koirala and L. Kuksa and H. Kunst and Y. Li and C. Magis-Escurra and V. Manfrin and S. Manga and K. Manika and V. Marchese and {Mart{\'i}nez Robles}, E. and A. Maryandyshev and A. Matteelli and A. Mariani and J. Mazza-Stalder and F. Mello and L. Mendoza and A. Mesi and S. Miliauskas and {Mustafa Hamdan}, H. and N. Ndjeka and {Nieto Marcos}, M. and T.H.M. Ottenhoff and D.J. Palmero and F. Palmieri and A. Papavasileiou and M.C. Payen and A. Pontarelli and {Pretti Dalcolmo}, M. and {Quir{\'o}s Fernandez}, S. and R. Romero and {Rossato Silva}, D. and A.P. Santos and B. Seaworth and M. Sinitsyn and A. Skrahina and I. Solovic and A. Spanevello and M. Tadolini and C. Torres and Z. Udwadia and {van den Boom}, M. and G.V. Volchenkov and A. Yedilbayev and R. Zaleskis and J.P. Zellweger and Network, {the members of the Global Tuberculosis}",

note = "Cited By :7 Export Date: 10 November 2020",

year = "2020",

doi = "10.1016/j.ijid.2020.01.042",

language = "English",

volume = "92",

pages = "S15--S25",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

TY - JOUR

T1 - MDR/XDR-TB management of patients and contacts:

T2 - Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

AU - Migliori, G.B.

AU - Tiberi, S.

AU - Zumla, A.

AU - Petersen, E.

AU - Chakaya, J.M.

AU - Wejse, C.

AU - Muñoz Torrico, M.

AU - Duarte, R.

AU - Alffenaar, J.W.

AU - Schaaf, H.S.

AU - Marais, B.J.

AU - Cirillo, D.M.

AU - Alagna, R.

AU - Rendon, A.

AU - Pontali, E.

AU - Piubello, A.

AU - Figueroa, J.

AU - Ferlazzo, G.

AU - García-Basteiro, A.

AU - Centis, R.

AU - Visca, D.

AU - D'Ambrosio, L.

AU - Sotgiu, G.

AU - Arkub, T.A.

AU - Akkerman, O.W.

AU - Aleksa, A.

AU - Belilovski, E.

AU - Bernal, E.

AU - Blanc, F.-X.

AU - Boeree, M.

AU - Borisov, S.

AU - Bruchfeld, J.

AU - Cadiñanos Loidi, J.

AU - Caminero, J.A.

AU - Carvalho, A.C.

AU - Cebrian Gallardo, J.J.

AU - Charalampos, null

AU - Danila, E.

AU - Davies Forsman, L.

AU - Denholm, J.

AU - Dheda, K.

AU - Diel, R.

AU - Diktanas, S.

AU - Dobler, C.

AU - Enwerem, M.

AU - Esposito, S.

AU - Escobar Salinas, N.

AU - Filippov, A.

AU - Formenti, B.

AU - García García, J.M.

AU - Goletti, D.

AU - Gomez Rosso, R.

AU - Gualano, G.

AU - Isaakidis, P.

AU - Kaluzhenina, A.

AU - Koirala, S.

AU - Kuksa, L.

AU - Kunst, H.

AU - Li, Y.

AU - Magis-Escurra, C.

AU - Manfrin, V.

AU - Manga, S.

AU - Manika, K.

AU - Marchese, V.

AU - Martínez Robles, E.

AU - Maryandyshev, A.

AU - Matteelli, A.

AU - Mariani, A.

AU - Mazza-Stalder, J.

AU - Mello, F.

AU - Mendoza, L.

AU - Mesi, A.

AU - Miliauskas, S.

AU - Mustafa Hamdan, H.

AU - Ndjeka, N.

AU - Nieto Marcos, M.

AU - Ottenhoff, T.H.M.

AU - Palmero, D.J.

AU - Palmieri, F.

AU - Papavasileiou, A.

AU - Payen, M.C.

AU - Pontarelli, A.

AU - Pretti Dalcolmo, M.

AU - Quirós Fernandez, S.

AU - Romero, R.

AU - Rossato Silva, D.

AU - Santos, A.P.

AU - Seaworth, B.

AU - Sinitsyn, M.

AU - Skrahina, A.

AU - Solovic, I.

AU - Spanevello, A.

AU - Tadolini, M.

AU - Torres, C.

AU - Udwadia, Z.

AU - van den Boom, M.

AU - Volchenkov, G.V.

AU - Yedilbayev, A.

AU - Zaleskis, R.

AU - Zellweger, J.P.

AU - Network, the members of the Global Tuberculosis

N1 - Cited By :7 Export Date: 10 November 2020

PY - 2020

Y1 - 2020

N2 - The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

AB - The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

U2 - 10.1016/j.ijid.2020.01.042

DO - 10.1016/j.ijid.2020.01.042

M3 - Article

VL - 92

SP - S15-S25

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -

MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

Abstract

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