Mealtime versus nighttime acid inhibition - A clinical pharmacological study with ranitidine

Vincenzo Savarino, Giuseppe Sandro Mela, Patrizia Zentilin, Sergio Vigneri, Patrizia Cutela, Raffaella Mele, Francesco Di Mario

Research output: Contribution to journalArticlepeer-review


This study was carried out in order to compare the effects of mealtime and bedtime regimens of ranitidine on gastric acidity. Fifteen duodenal ulcer pateints in clinical remission were randomized to receive in single-blind fashion either placebo, ranitidine 300 mg at night (2200 hr) or ranitidine 150 mg three times a day given before each of the three daily meals (1800, 0800 and 1200 hr). Over 24 hr, the two active treatments produced a significantly greater acid inhibition than placebo, while the single daily regimen was superior to the three times a day regimen of ranitidine in terms of both rise in pH values (P

Original languageEnglish
Pages (from-to)1368-1372
Number of pages5
JournalDigestive Diseases and Sciences
Issue number9
Publication statusPublished - Sep 1992


  • bedtime dose
  • gastric acidity
  • mealtime doses
  • pH monitoring
  • ranitidine

ASJC Scopus subject areas

  • Gastroenterology


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