Mean platelet volume is associated with lower risk of overall and non-vascular mortality in a general population: Results from the Moli-sani study

Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Amalia de Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Jos Vermylen, Ignacio de Paula Carrasco, Simona Giampaoli, Antonio Spagnuolo, Deodato Assanelli, Vincenzo Centritto, Pasquale Spagnuolo, Dante Staniscia, Americo Bonanni, Roberto Lorenzet, Antonio MascioliDomenico Rotilio, Marco Olivieri, Maurizio Giacci, Antonella Padulo, Dario Petraroia, Claudio Grippi, Maria Spinelli, Christian Silvestri, Francesco Gianfagna, Angelita Verna, Agnieszka Pampuch, Branislav Vohnout, Agostino Pannichella, Antonio Rinaldo Vizzarri, Antonella Arcari, Daniela Barbato, Francesca Bracone, Carmine Di Giorgio, Sara Magnacca, Simona Panebianco, Antonello Chiovitti, Federico Marracino, Sergio Caccamo, Vanesa Caruso, Daniela Cugino, Francesco Zito, Alessandra Ferri, Marcella Mignogna, Tomasz Guszcz, Romina Di Giuseppe, Moli-sani Study Investigators

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Abstract

Larger mean platelet volume (MPV) has been associated with adverse health outcomes in high-risk populations or patients with cardiovascular disease (CVD). We tested the association of MPV with mortality in a prospective cohort study including 17,402 subjects randomly recruited from an adult general population within the Moli-sani study (2005-2010). Two distinct subgroups (with or without CVD at baseline) were subsequently analysed. Hazard ratios (HR) were calculated using multivariable Cox-proportional hazard models. Over a median follow up of eight years (137,547 person-years), 925 all-cause deaths occurred (330 vascular, 351 cancer and 244 other deaths). In a multivariable model, the highest MPV quintile (mean MPV=10.0 fL), as compared to the lowest one, was associated with reduced risk of overall mortality (HR=0.79; 95 % confidence interval 0.64-0.98), cancer death (HR=0.70; 0.49-1.00) and death from other non-vascular/non cancer causes (HR=0.55; 0.36-0.84) but not with vascular mortality. The inverse association with overall death appeared even stronger in the subgroup without CVD at baseline (HR=0.64; 0.50-0.81). In contrast, within 920 subjects reporting a previous CVD event, larger MPV was associated with higher risk of total mortality (HR=1.69; 1.05-2.72; p for interaction=0.048) and with a trend of risk for other cause-specific deaths. In conclusion, larger MPV is associated with lower risk of overall and non-vascular death in subjects apparently free from CVD, but appears to be a predictive marker of death in patients with CVD history. The latter is a likely effect modifier of the association between MPV and death.

Original languageEnglish
Pages (from-to)1129-1140
Number of pages12
JournalThrombosis and Haemostasis
Volume117
Issue number6
DOIs
Publication statusPublished - Jun 2 2017

Keywords

  • Cardiovascular disease
  • Cerebrovascular disease
  • Epidemiology
  • Mean platelet volume
  • Mortality

ASJC Scopus subject areas

  • Hematology

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    Bonaccio, M., Di Castelnuovo, A., Costanzo, S., de Curtis, A., Persichillo, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Vermylen, J., de Paula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Spagnuolo, P., Staniscia, D., Bonanni, A., Lorenzet, R., ... Moli-sani Study Investigators (2017). Mean platelet volume is associated with lower risk of overall and non-vascular mortality in a general population: Results from the Moli-sani study. Thrombosis and Haemostasis, 117(6), 1129-1140. https://doi.org/10.1160/TH16-12-0974