Measles serological survey in the Italian population: Interpretation of results using mixture model

Maria Cristina Rota, Marco Massari, Giovanni Gabutti, Marcello Guido, Antonella De Donno, Marta Luisa Ciofi degli Atti

Research output: Contribution to journalArticlepeer-review

Abstract

In 2003-2004, a national measles seroprevalence study was conducted in Italy and data were analysed by using both commercial ELISA cut-off, and by applying a mixture model. Results of the two methods were compared and interpreted in the light of measles incidence, vaccination coverage and previous seroprevalence data. Seroprevalence rates observed in 2004 were similar to those observed in a previous study conducted in 1996 for children up to 9 years of age, while they were significantly lower in individuals aged 10-19 years. Mixture model approach allowed to better understand these results, suggesting that in these latter age groups there was a waning of vaccine-induced immunity mainly in Northern-Central regions which historically had the highest vaccination coverage.

Original languageEnglish
Pages (from-to)4403-4409
Number of pages7
JournalVaccine
Volume26
Issue number34
DOIs
Publication statusPublished - Aug 12 2008

Keywords

  • Italy
  • Measles
  • Mixture model
  • Seroprevalence

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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