Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition

Heather A. Ward, Petra A. Wark, David C. Muller, Annika Steffen, Mattias Johansson, Teresa Norat, Marc J. Gunter, Kim Overvad, Christina C. Dahm, Jytte Halkjær, Anne Tjønneland, Marie Christine Boutron-Ruault, Guy Fagherazzi, Sylvie Mesrine, Paul Brennan, Heinz Freisling, Kuanrong Li, Rudolf Kaaks, Antonia Trichopoulou, Pagona LagiouSalavatore Panico, Sara Grioni, Rosario Tumino, Paolo Vineis, Domenico Palli, Petra H.M. Peeters, H. Bas Bueno-De-Mesquita, Elisabete Weiderpass, Antonio Agudo, Jose Ramon Quiros, Nerea Larranaga, Eva Ardanaz, Jose María Huerta, María Jose Sanchez, Goran Laurell, Ingegerd Johansson, Ulla Westin, Peter Wallstrom, Kathryn E. Bradbury, Nicholas J. Wareham, Kay Tee Khaw, Clare Pearson, Heiner Boeing, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error. Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: 30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models. Results: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95%confidence interval (CI), 1.23-2.12)];BMIwasnot associated with headandneck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm:HR, 1.08; 95% CI, 1.02-1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction=0.004). Among men,WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21-1.65). Conclusions: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated. Impact: Strategies to reduce obesity may beneficially impact head and neck cancer incidence.

Original languageEnglish
Pages (from-to)895-904
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

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ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Ward, H. A., Wark, P. A., Muller, D. C., Steffen, A., Johansson, M., Norat, T., Gunter, M. J., Overvad, K., Dahm, C. C., Halkjær, J., Tjønneland, A., Boutron-Ruault, M. C., Fagherazzi, G., Mesrine, S., Brennan, P., Freisling, H., Li, K., Kaaks, R., Trichopoulou, A., ... Riboli, E. (2017). Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition. Cancer Epidemiology Biomarkers and Prevention, 26(6), 895-904. https://doi.org/10.1158/1055-9965.EPI-16-0886