Abstract
The purpose of this study was to register the accuracy and reproducibility of the multidetector computed tomography (MDCT) estimate of hypopharyngeal and laryngeal tumor volumes. Eighteen consecutive patients with larynx or hypopharynx squamous cell carcinoma were enrolled in this prospective trial, scheduled for surgery and examined by MDCT. A total of 72 tumor volume measurements were reported by two different operators, one of them in three different sessions, using the sum-of-areas method. The results were compared with the volume calculated by surgical sampling. The mean tumor volume measured by MDCT was 5.7±9.3 ml (range 0.1-41.6). The mean volume measured from the surgical specimens was 5.6±8.6 ml (range 0.06-33.6). The level of agreement between histological and MDCT volumes was high, with a slight tendency of MDCT to overestimation, proportional to the size. The analysis of interoperator variability showed a tendency of the more expert operator to make more accurate estimates, but the differences were not significant (P = 0.62, 0.75 and 0.63). The evaluation of the three different sessions of the less expert operator revealed a good repeatability. According to our study, MDCT estimate of tumor volume is an effective, reproducible method. MDCT tends to produce more dispersed results in case of large tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 2096-2102 |
| Number of pages | 7 |
| Journal | European Radiology |
| Volume | 17 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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Keywords
- Computed tomography
- CT tumor volume
- Head and neck neoplasms
- Observer performance
- Pharynx
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Measurement by multidetector CT scan of the volume of hypopharyngeal and laryngeal tumours : Accuracy and reproducibility. / Preda, Lorenzo; Lovati, Elena; Chiesa, Fausto; Ansarin, Mohssen; Cattaneo, Laura; Fasani, Roberta; Gandini, Sara; Flor, Nicola; Cornalba, Gianpaolo; Bellomi, Massimo.
In: European Radiology, Vol. 17, No. 8, 08.2007, p. 2096-2102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement by multidetector CT scan of the volume of hypopharyngeal and laryngeal tumours
T2 - Accuracy and reproducibility
AU - Preda, Lorenzo
AU - Lovati, Elena
AU - Chiesa, Fausto
AU - Ansarin, Mohssen
AU - Cattaneo, Laura
AU - Fasani, Roberta
AU - Gandini, Sara
AU - Flor, Nicola
AU - Cornalba, Gianpaolo
AU - Bellomi, Massimo
PY - 2007/8
Y1 - 2007/8
N2 - The purpose of this study was to register the accuracy and reproducibility of the multidetector computed tomography (MDCT) estimate of hypopharyngeal and laryngeal tumor volumes. Eighteen consecutive patients with larynx or hypopharynx squamous cell carcinoma were enrolled in this prospective trial, scheduled for surgery and examined by MDCT. A total of 72 tumor volume measurements were reported by two different operators, one of them in three different sessions, using the sum-of-areas method. The results were compared with the volume calculated by surgical sampling. The mean tumor volume measured by MDCT was 5.7±9.3 ml (range 0.1-41.6). The mean volume measured from the surgical specimens was 5.6±8.6 ml (range 0.06-33.6). The level of agreement between histological and MDCT volumes was high, with a slight tendency of MDCT to overestimation, proportional to the size. The analysis of interoperator variability showed a tendency of the more expert operator to make more accurate estimates, but the differences were not significant (P = 0.62, 0.75 and 0.63). The evaluation of the three different sessions of the less expert operator revealed a good repeatability. According to our study, MDCT estimate of tumor volume is an effective, reproducible method. MDCT tends to produce more dispersed results in case of large tumors.
AB - The purpose of this study was to register the accuracy and reproducibility of the multidetector computed tomography (MDCT) estimate of hypopharyngeal and laryngeal tumor volumes. Eighteen consecutive patients with larynx or hypopharynx squamous cell carcinoma were enrolled in this prospective trial, scheduled for surgery and examined by MDCT. A total of 72 tumor volume measurements were reported by two different operators, one of them in three different sessions, using the sum-of-areas method. The results were compared with the volume calculated by surgical sampling. The mean tumor volume measured by MDCT was 5.7±9.3 ml (range 0.1-41.6). The mean volume measured from the surgical specimens was 5.6±8.6 ml (range 0.06-33.6). The level of agreement between histological and MDCT volumes was high, with a slight tendency of MDCT to overestimation, proportional to the size. The analysis of interoperator variability showed a tendency of the more expert operator to make more accurate estimates, but the differences were not significant (P = 0.62, 0.75 and 0.63). The evaluation of the three different sessions of the less expert operator revealed a good repeatability. According to our study, MDCT estimate of tumor volume is an effective, reproducible method. MDCT tends to produce more dispersed results in case of large tumors.
KW - Computed tomography
KW - CT tumor volume
KW - Head and neck neoplasms
KW - Observer performance
KW - Pharynx
UR - http://www.scopus.com/inward/record.url?scp=34547138891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547138891&partnerID=8YFLogxK
U2 - 10.1007/s00330-006-0573-y
DO - 10.1007/s00330-006-0573-y
M3 - Article
VL - 17
SP - 2096
EP - 2102
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 8
ER -