Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis

M. P. Sormani, M. Rovaris, P. Valsasina, J. S. Wolinsky, G. Comi, M. Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.

Original languageEnglish
Pages (from-to)1432-1434
Number of pages3
JournalNeurology
Volume62
Issue number8
Publication statusPublished - Apr 27 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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