Measurement of bile acid half-life using [75Se]HCAT in health and intestinal diseases - Comparison with [75Se]HCAT abdominal retention methods

R. Ferraris, G. Galatola, A. Barlotta, R. Pellerito, M. Fracchia, F. Cottino, M. De La Pierre

Research output: Contribution to journalArticlepeer-review

Abstract

The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predictive value, and 78% negative predictive value at the optimal cutoff level of 2.0 days; lower-but not significantly different-figures were observed for [75Se]HCAT total abdominal retention four and seven days after isotope administration, at the optimal cutoff levels of 40% and 22%, respectively. [75Se]HCAT T1/2 was then evaluated in 60 patients with various intestinal diseases. Sixty-nine percent (9/13) of patients with diarrhea of obscure origin showed abnormal [75Se]HCAT T1/2. Bile acid malabsorption using [75Se]HCAT can be investigated by the noninvasive measurement of its enterohepatic T1/2 and may play a pathogenetic role in patients with diarrhea of obscure origin.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalDigestive Diseases and Sciences
Volume37
Issue number2
DOIs
Publication statusPublished - Feb 1992

Keywords

  • [Se]HCAT
  • bile acid malabsorption
  • bile acids
  • diarrhea

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint

Dive into the research topics of 'Measurement of bile acid half-life using [<sup>75</sup>Se]HCAT in health and intestinal diseases - Comparison with [<sup>75</sup>Se]HCAT abdominal retention methods'. Together they form a unique fingerprint.

Cite this