Measurement of central corneal thickness with optical low-coherence reflectometry and ultrasound pachymetry in normal and post-femtosecond laser in situ keratomileusis eyes

Jinhai Huang, Na Liao, Giacomo Savini, Yuanguang Li, Fangjun Bao, Ye Yu, Ayong Yu, Qinmei Wang

Research output: Contribution to journalArticle


Purpose: To determine the repeatability and reproducibility of measurements of central corneal thickness (CCT) using optical lowcoherence reflectometry (Lenstar LS900; Haag Streit) in normal eyes and post-femtosecond laser in situ keratomileusis (post-FS-LASIK) eyes and evaluate their agreement with ultrasound (US) pachymetry. Methods: CCT was measured using Lenstar and US pachymetry sequentially in normal and post-FS-LASIK eyes by 2 experienced observers. Intraoperator repeatability and interoperator reproducibility were assessed by within-subject standard deviation, test-retest repeatability, coefficient of variation (CoV), and intraclass correlation coefficient. Paired t-tests and Bland-Altman plots were used for analyzing agreement between the 2 devices. Results: In this study, 55 healthy subjects and 50 post-FS-LASIK patients were recruited. Test-retest repeatability of Lenstar was within 10 μm, CoV was less than 1.0%, and intraclass correlation coefficient was more than 0.9 in both normal and post-FS-LASIK groups. Mean difference between these methods was 1.4 ± 4.2 μm and -1.7 ± 5.4 μm, respectively. Moreover, measurements of CCT showed narrow 95% limits of agreement (range, normal group: 26.8 and 9.6 μm; post-FS-LASIK group: -12.4 and 8.9 μm), which implied good agreement. Conclusions: Measurements of CCT using Lenstar showed excellent intraoperator repeatability and interoperator reproducibility both in normal eyes and post-FS-LASIK eyes. Measurements of CCT using Lenstar and US pachymetry showed good agreement and both can be used interchangeably.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
Issue number2
Publication statusPublished - Feb 1 2015



  • Agreement
  • Corneal thickness
  • Femtosecond
  • Laser in situ keratomileusis
  • Optical low-coherence reflectometry
  • Precision

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

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