Measurement of cerebrospinal fluid flow: Technique validation in a patient with idiopathic normal pressure hydrocephalus

A. Romano, A. Bozzao, G. Trillò, M. Bonamini, F. Fasoli, E. Giugni, M. Ferrante, V. Finocchi, L. M. Fantozzi, L. Ferrante

Research output: Contribution to journalArticlepeer-review


This study aimed to assess anatomical and functional changes disclosed by magnetic resonance imaging in a patient with suspect normal pressure hydrocephalus following surgical third ventriculostomy with placement of a ventriculoperitoneal shunt. The patient was investigated by phase contrast sequences to calculate CSF flow in the Sylvian aqueduct before and after the two surgical procedures. In addition, T1-weighted volumetric MPRAGE images were acquired using voxel-based morphometry to study any changes in size of the ventricular system and CSF in the subarachnoid spaces before and after surgery. CSF flow measurements were closely correlated with the patient's clinical course, increased CSF flow coinciding with worsening symptoms, and a decrease in flow noted after surgery. There were no significant changes in the CSF volumes analyzed. Phase contrast technique proved reliable and effective for the purposes of diagnosis and long-term follow-up in patients with suspect normal pressure hydrocephalus eligible for surgery.

Original languageEnglish
Pages (from-to)34-36
Number of pages3
JournalRivista di Neuroradiologia
Issue number1
Publication statusPublished - Feb 2005


  • Normal pressure hydrocephalus
  • Phase-contrast sequence
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology


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