Measurement of fetal surfactant production by fluorescence polarization of amniotic fluid in complicated pregnancies

P. Masturzo, M. Salmona, G. Rossi, M. Luerti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The results are presented of fluorescence polarization as a method for measurement of surfactant production in 159 specimens of amniotic fluid collected from pregnant women with diabetes, hypertension, Rh immunization, premature rupture of membranes (for more than 48 h prior to delivery) and intrauterine growth retardation (IUGR). The predictability of the development of respiratory distress syndrome has been assessed by this assay. Its specificity, sensitivity and overall accuracy were similar to the lecithin sphingomyelin (L S) ratio. The influence of the conditions detailed on fetal lung maturation was determined, lung development being enhanced until near term by Rh immunization, rupture of membranes and hypertension with IUGR.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalClinica Chimica Acta
Volume168
Issue number2
DOIs
Publication statusPublished - Sep 30 1987

Fingerprint

Immunization
Fluorescence Polarization
Fetal Growth Retardation
Amniotic Fluid
Surface-Active Agents
Rupture
Fluorescence
Polarization
Hypertension
Membranes
Pregnancy
Lung
Fluids
Sphingomyelins
Lecithins
Medical problems
Pregnant Women
Assays
Sensitivity and Specificity

Keywords

  • Amniotic fluid
  • Fetal surfactant
  • Fluorescence polarization

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Measurement of fetal surfactant production by fluorescence polarization of amniotic fluid in complicated pregnancies. / Masturzo, P.; Salmona, M.; Rossi, G.; Luerti, M.

In: Clinica Chimica Acta, Vol. 168, No. 2, 30.09.1987, p. 137-142.

Research output: Contribution to journalArticle

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