TY - JOUR
T1 - Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
AU - Brunetti, Arturo
AU - Postiglione, Alfredo
AU - Tedeschi, Enrico
AU - Ciarmiello, Andrea
AU - Quarantelli, Mario
AU - Covelli, Eugenio M.
AU - Milan, Graziella
AU - Larobina, Michele
AU - Soricelli, Andrea
AU - Sodano, Antonio
AU - Alfano, Bruno
PY - 2000/3
Y1 - 2000/3
N2 - In 16 patients with probable Alzheimer's disease (AD; NINDS criteria, age range 56-78 years), gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) absolute and fractional volumes were measured with an unsupervised multiparametric post-processing segmentation method based on estimates of relaxation rates R1, R2 (R1 = 1/T1; R2 = 1/T2) and proton density [N(H)] from conventional spin-echo studies (Alfano et al. Magn. Reson. Med. 1997;37:84-93). Global brain atrophy, and GM and WM fractions significantly correlated with Mini-Mental Status Examination and Blessed Dementia Scale scores. Compared with normals, brain compartments in AD patients showed decreased GM (-6.84 ± 1.58%) and WM fractions (-9.79 ± 2.47%) and increased CSF fractions (+58.80 ± 10.37%). Changes were more evident in early-onset AD patients. In AD, measurement of global brain atrophy obtained by a computerized procedure based on routine magnetic resonance studies could complement the information provided by neuropsychological tests for the assessment of disease severity. (C) 2000 Wiley-Liss, Inc.
AB - In 16 patients with probable Alzheimer's disease (AD; NINDS criteria, age range 56-78 years), gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) absolute and fractional volumes were measured with an unsupervised multiparametric post-processing segmentation method based on estimates of relaxation rates R1, R2 (R1 = 1/T1; R2 = 1/T2) and proton density [N(H)] from conventional spin-echo studies (Alfano et al. Magn. Reson. Med. 1997;37:84-93). Global brain atrophy, and GM and WM fractions significantly correlated with Mini-Mental Status Examination and Blessed Dementia Scale scores. Compared with normals, brain compartments in AD patients showed decreased GM (-6.84 ± 1.58%) and WM fractions (-9.79 ± 2.47%) and increased CSF fractions (+58.80 ± 10.37%). Changes were more evident in early-onset AD patients. In AD, measurement of global brain atrophy obtained by a computerized procedure based on routine magnetic resonance studies could complement the information provided by neuropsychological tests for the assessment of disease severity. (C) 2000 Wiley-Liss, Inc.
KW - Alzheimer's disease
KW - Brain atrophy
KW - Brain segmentation
KW - Cognitive assessment
KW - Magnetic resonance
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U2 - 10.1002/(SICI)1522-2586(200003)11:3<260::AID-JMRI4>3.0.CO;2-I
DO - 10.1002/(SICI)1522-2586(200003)11:3<260::AID-JMRI4>3.0.CO;2-I
M3 - Article
C2 - 10739557
AN - SCOPUS:0034050812
VL - 11
SP - 260
EP - 266
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 3
ER -