Abstract
Objectives: To assess prospectively the agreement of orocaecal transit time (OCTT) measurements by lactulose hydrogen breath test (LHBT) and magnetic resonance imaging (MRI) in healthy subjects. Methods: Volunteers underwent abdominal 1.5-T MRI using axial and coronal single-shot fast-spin-echo T2-weighted sequences, having fasted and after lactulose ingestion (10 g/125 mL). Imaging and H2 excretion gas-chromatography were performed concurrently every 15 min up to 180 min. MR images were analyzed using semiautomatic segmentation to calculate small bowel gas volume (SBGV) and visually to detect bolus arrival in the caecum. Agreement between MRI- and LHBT-OCTT was assessed. Results: Twenty-eight subjects (17 men/11 women; mean age ± standard deviation 30 ± 8 years) were evaluated. Two H2 non-producers on LHBT were excluded. OCTT measured by MRI and LHBT was concordant in 18/26 (69 %) subjects (excellent agreement, k = 0.924). Median SBGV was 49.0 mL (interquartile interval 44.1 – 51.6 mL). In 8/26 (31 %) subjects, MRI showed that the lactulose bolus was in the terminal ileum and not the caecum when H2E increased on LHBT. Median OCTT measured by MRI was significantly longer than OCTT measured by LHBT [135 min (120 – 150 min) vs. 127.5 min (105 – 150 min); p = 0.008]. Above baseline levels, correlation between [H2] and SBGV was significant (r = 0.964; p <0.001). Conclusions: MRI provides valid measurements of OCTT and gas production in the small bowel. Key Points: • MRI is a valid technique to measure OCTT. • Excellent agreement between MRI and LHBT was found. • Measuring gas production using MRI may provide evidence of small bowel fermentation.
| Original language | English |
|---|---|
| Pages (from-to) | 1579-1587 |
| Number of pages | 9 |
| Journal | European Radiology |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2015 |
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Keywords
- Irritable bowel syndrome
- Lactulose hydrogen breath test
- Magnetic resonance imaging
- Orocaecal transit time
- Small bowel
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Measurement of oro-caecal transit time by magnetic resonance imaging. / Savarino, Edoardo; Savarino, Vincenzo; Fox, Mark; Di Leo, Giovanni; Furnari, Manuele; Marabotto, Elisa; Gemignani, Lorenzo; Bruzzone, Luca; Moscatelli, Alessandro; De Cassan, Chiara; Sardanelli, Francesco; Sconfienza, Luca Maria.
In: European Radiology, Vol. 25, No. 6, 01.06.2015, p. 1579-1587.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement of oro-caecal transit time by magnetic resonance imaging
AU - Savarino, Edoardo
AU - Savarino, Vincenzo
AU - Fox, Mark
AU - Di Leo, Giovanni
AU - Furnari, Manuele
AU - Marabotto, Elisa
AU - Gemignani, Lorenzo
AU - Bruzzone, Luca
AU - Moscatelli, Alessandro
AU - De Cassan, Chiara
AU - Sardanelli, Francesco
AU - Sconfienza, Luca Maria
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Objectives: To assess prospectively the agreement of orocaecal transit time (OCTT) measurements by lactulose hydrogen breath test (LHBT) and magnetic resonance imaging (MRI) in healthy subjects. Methods: Volunteers underwent abdominal 1.5-T MRI using axial and coronal single-shot fast-spin-echo T2-weighted sequences, having fasted and after lactulose ingestion (10 g/125 mL). Imaging and H2 excretion gas-chromatography were performed concurrently every 15 min up to 180 min. MR images were analyzed using semiautomatic segmentation to calculate small bowel gas volume (SBGV) and visually to detect bolus arrival in the caecum. Agreement between MRI- and LHBT-OCTT was assessed. Results: Twenty-eight subjects (17 men/11 women; mean age ± standard deviation 30 ± 8 years) were evaluated. Two H2 non-producers on LHBT were excluded. OCTT measured by MRI and LHBT was concordant in 18/26 (69 %) subjects (excellent agreement, k = 0.924). Median SBGV was 49.0 mL (interquartile interval 44.1 – 51.6 mL). In 8/26 (31 %) subjects, MRI showed that the lactulose bolus was in the terminal ileum and not the caecum when H2E increased on LHBT. Median OCTT measured by MRI was significantly longer than OCTT measured by LHBT [135 min (120 – 150 min) vs. 127.5 min (105 – 150 min); p = 0.008]. Above baseline levels, correlation between [H2] and SBGV was significant (r = 0.964; p <0.001). Conclusions: MRI provides valid measurements of OCTT and gas production in the small bowel. Key Points: • MRI is a valid technique to measure OCTT. • Excellent agreement between MRI and LHBT was found. • Measuring gas production using MRI may provide evidence of small bowel fermentation.
AB - Objectives: To assess prospectively the agreement of orocaecal transit time (OCTT) measurements by lactulose hydrogen breath test (LHBT) and magnetic resonance imaging (MRI) in healthy subjects. Methods: Volunteers underwent abdominal 1.5-T MRI using axial and coronal single-shot fast-spin-echo T2-weighted sequences, having fasted and after lactulose ingestion (10 g/125 mL). Imaging and H2 excretion gas-chromatography were performed concurrently every 15 min up to 180 min. MR images were analyzed using semiautomatic segmentation to calculate small bowel gas volume (SBGV) and visually to detect bolus arrival in the caecum. Agreement between MRI- and LHBT-OCTT was assessed. Results: Twenty-eight subjects (17 men/11 women; mean age ± standard deviation 30 ± 8 years) were evaluated. Two H2 non-producers on LHBT were excluded. OCTT measured by MRI and LHBT was concordant in 18/26 (69 %) subjects (excellent agreement, k = 0.924). Median SBGV was 49.0 mL (interquartile interval 44.1 – 51.6 mL). In 8/26 (31 %) subjects, MRI showed that the lactulose bolus was in the terminal ileum and not the caecum when H2E increased on LHBT. Median OCTT measured by MRI was significantly longer than OCTT measured by LHBT [135 min (120 – 150 min) vs. 127.5 min (105 – 150 min); p = 0.008]. Above baseline levels, correlation between [H2] and SBGV was significant (r = 0.964; p <0.001). Conclusions: MRI provides valid measurements of OCTT and gas production in the small bowel. Key Points: • MRI is a valid technique to measure OCTT. • Excellent agreement between MRI and LHBT was found. • Measuring gas production using MRI may provide evidence of small bowel fermentation.
KW - Irritable bowel syndrome
KW - Lactulose hydrogen breath test
KW - Magnetic resonance imaging
KW - Orocaecal transit time
KW - Small bowel
UR - http://www.scopus.com/inward/record.url?scp=84930004818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930004818&partnerID=8YFLogxK
U2 - 10.1007/s00330-014-3575-1
DO - 10.1007/s00330-014-3575-1
M3 - Article
C2 - 25576231
AN - SCOPUS:84930004818
VL - 25
SP - 1579
EP - 1587
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 6
ER -