Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model

Chiara Dalla Man, Andrea Caumo, Rita Basu, Robert Rizza, Gianna Toffolo, Claudio Cobelli

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The oral glucose minimal model (OMM) measures insulin sensitivity (S I) and the glucose rate of appearance (Ra) of ingested glucose in the presence of physiological changes of insulin and glucose concentrations. However, SI of OMM measures the overall effect of insulin on glucose utilization and glucose production. In this study we show that, by adding a tracer to the oral dose, e.g., of a meal, and by using the labeled version of OMM, OMM* to interpret the data, one can measure the selective effect of insulin on glucose disposal, S*I Eighty-eight individuals underwent both a triple-tracer meal with the tracer-to-tracee clamp technique, providing a model-independent reference of the Ra of ingested glucose (Ra meal ref) and an insulin-modified labeled intravenous glucose tolerance test (IVGTT*). We show that OMM* provides not only a reliable means of tracing the R a of ingested glucose (Ra meal) but also accurately measures S*I. We do so by comparing OMM* R a meal with the model-independent Ra meal ref provided by the tracer-to-tracee clamp technique, while OMM* S*I is compared with both S*I ref, obtained by using as known input Ra meal ref and with S*I measured during IVGTT*.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume289
Issue number5 52-5
DOIs
Publication statusPublished - Nov 2005

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Insulin
Glucose
Meals
Glucose Tolerance Test
Clamping devices
Insulin Resistance

Keywords

  • Glucose utilization
  • Insulin action
  • Intravenous glucose tolerance test
  • Oral glucose tolerance test
  • Tracer-to-tracee activity clamp

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model. / Dalla Man, Chiara; Caumo, Andrea; Basu, Rita; Rizza, Robert; Toffolo, Gianna; Cobelli, Claudio.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 289, No. 5 52-5, 11.2005.

Research output: Contribution to journalArticle

Dalla Man, Chiara ; Caumo, Andrea ; Basu, Rita ; Rizza, Robert ; Toffolo, Gianna ; Cobelli, Claudio. / Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model. In: American Journal of Physiology - Endocrinology and Metabolism. 2005 ; Vol. 289, No. 5 52-5.
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