Measurement of skeletal muscle mass in Duchenne muscular dystrophy: Use of 24-h creatinine excretion

D. Franciotta, M. C. Zanardi, L. Albertotti, S. Orcesi, A. Berardinelli, A. Pichiecchio, C. Uggetti, A. Tagliabue

Research output: Contribution to journalArticle

Abstract

Creatinine concentration in 24-h urine has been proposed as an indirect measure of body skeletal muscle mass (SMM). We attempted to correlate urinary creatinine levels with SMM in eight patients with Duchenne muscular dystrophy, a progressive disease in which the degree of muscle wasting parallels the rate of progression. Magnetic resonance imaging and a newly developed protocol for image analysis were used for the measurement of SMM. The patients ate a creatine-free diet for the week before urine collection. Creatinine was measured with an enzymatic-colorimetric method. Mean (±SD) SMM value was 5.4±2.5 kg and urine creatinine levels 205.8±96.4 mg/day. Daily urinary creatinine excretion did not correlate with SMM. The simple creatinine determination in urine cannot predict SMM in Duchenne muscular dystrophy.

Original languageEnglish
JournalActa Diabetologica
Volume40
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 2003

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Keywords

  • Creatinine excretion
  • Magnetic resonance imaging
  • Skeletal muscle mass

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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