The commonest interpretation criteria based on the analysis of pulmonary nitrogen clearance curve, applied to the study of gas distribution and to the measure of ventilatory efficiency in health and in respiratory disease, have been analyzed. The present report concerns the functional indices expressing the degree of nonuniformity of gas distribution and ventilatory efficiency, calculated as the total ventilation of oxygen required to lower the end-tidal nitrogen concentration to a conventional value. It has been pointed out that the commonest data obtained by the analysis of nitrogen washout curve provide a reliable measure of the severity of chronic obstructive pulmonary disease. Moreover, the results obtained show that certain indices derived from nitrogen washout curve are related to current spirometric and plethysmographic data and to arterial blood gases, especially as regards the presence and degree of hypoxemia. In conclusion, our data suggest that nitrogen clearance technique is not a particularly sensitive test for the early detection of bronchial obstruction.
|Number of pages||5|
|Publication status||Published - 1978|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine